This work was supported by the National Natural Science Foundation of China(31500703,31371351,and 31671488);the Program for New Century Excellent Talents in University of China(NCET-09-0737).
The p53 pathway is a highly complex signaling network including several key regulators.HAUSP is a critical component of the p53 pathway acting as a deubiquitinase for both p53 and its key repressor Mdm2.Here,we identi...
This work was supported by grants received from Council of Scientific and Industrial Research(CSIR),DST(DST-Nanomission-SR/NM/NS-1058/2015);DBT(Bio-cluster,Kolkata),Govt.of India.
Herpesvirus-associated ubiquitin-specific protease(HAUSP)is a USP family deubiquitinase.HAUSP is a protein of immense biological importance as it is involved in several cellular processes,including host-virus interact...
Neuroblastoma (NBL) is one of the most common solid tumors and around 15% of cancer mortality in children. Amplification of the N-Myc proto-oncogene is strongly correlated with advanced disease and poor clinical outco...
It is well established that both p53 and MDM2 are short-lived proteins whose stabilities are tightly controlled through ubiquitination-mediated degradation. Although numerous studies indicate that the MDM2 E3 ligase a...