Menopause and cognitive impairment:A narrative review of current knowledge  

作　　者：Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva 

机构地区：[1]Department of Gynecology and Obstetrics,Federal University of Goiás,Goiânia 74605-050,Goiás,Brazil [2]Department of Obstetrics and Gynecology,School of Medical Sciences,State University of Campinas,Campinas 13083-881,São Paulo,Brazil [3]Department of Medical Psychology and Psychiatry-Geriatric Psychiatry and Neuropsychiatric Division,State University of Campinas,Campinas 13083-887,São Paulo,Brazil

出　　处：《World Journal of Psychiatry》2021年第8期412-428,共17页世界精神病学杂志

基　　金：Supported by National Council for Scientific and Technological Development of Brazil(CNPq),No.312400/2018-7.

摘　　要：A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition.

关 键 词：MENOPAUSE COGNITION DEMENTIA ESTROGENS Hot flashes Cognitive decline 

分 类 号：R749.1[医药卫生—神经病学与精神病学]