Macrophage Dicer promotes tolerogenic apoptotic cell clearance and immune tolerance by inhibiting pentose phosphate pathway activity  

作　　者：Qiangdongzi Mao Bangwei Luo Jie Mei Wenhua Li Xue Zhang Zhiyu Wang Jiechun Zhang Tingting Liu Fengxue Zhang Zhiren Zhang 

机构地区：[1]Research Center for Integrative Medicine of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong,China [2]Institute of Immunology,Army Medical University,Chongqing,China [3]Department of Respiratory Medicine,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong,China

出　　处：《Cellular & Molecular Immunology》2021年第7期1841-1843,共3页中国免疫学杂志（英文版）

基　　金：supported by a grant(2016YFA0502201)from the National Key Research Program of China(Z.Z.)and grants(81671559 and 82071778)from the National Natural Science Foundation of China(Z.Z.).

摘　　要：Given that apoptosis is the dominant modality of homeostatic cell turnover,efficient clearance of apoptotic cells(ACs),which is a process known as efferocytosis,is critical for immune homeostasis.The phagocytic engulfment of ACs occurs through an immunologically silent process to prevent an immune response to self-antigens.Correspondingly,defects in the removal of ACs have been proposed to underlie the pathogenesis of systemic lupus erythematosus(SLE).1,2 However,pathways that regulate phagocytes for efficient immune-silent AC uptake remain to be fully elucidated.Dicer is best known for its role as a riboendonuclease in the biogenesis of microRNAs.3 While recent studies have determined a link between microRNAs and AC clearance,the interplay between Dicer and efferocytosis remains unknown.

关 键 词：INHIBITING HOMEOSTASIS APO 

分 类 号：R392[医药卫生—免疫学]