Lung stem cells in regeneration and tumorigenesis  

作　　者：Yuting Chen Yun Xue Yujuan Jin Hongbin Ji 

机构地区：[1]State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China [2]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China [3]Shanghai Pulmonary Hospital,Tongji University,Shanghai 200092,China

出　　处：《Journal of Genetics and Genomics》2021年第4期268-276,共9页遗传学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(81402371 to Y.J.,82030083 to H.J.,91731314 H.J.,81872312 to H.J.,82011540007 to H.J.,31621003 to H.J.);the National Basic Research Program of China(2017YFA0505501 to H.J.;2020YFA0803300 to H.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19020201 to H.J.);the Basic Frontier Scientific Research Program of Chinese Academy of Science(ZDBS-LY-SM006 to H.J.);the International Cooperation Project of Chinese Academy of Sciences(153D31KYSB20190035 to H.J.)。

摘　　要：Adult lung is a highly quiescent organ,with extremely low cell turnover frequency.However,emerging evidences support the occurrence of repair and regeneration in pulmonary epithelia in response to various injuries.Lung regeneration mainly depends on the proliferation of regionally distributed pulmonary stem cells that re-enter the cell cycle.Genetic lineage-tracing approaches help to track the lung epithelial differentiation and/or de-differentiation path,and single-cell transcriptomic technique reveals the essential molecular signaling involved in lung regeneration.Dysregulation of the molecular signaling that balances quiescence and self-renewal leads to the transformation of lung stem cells,and thus promotes lung cancer development.Interestingly,different subtypes of lung cancer share common cells of origin and the pathological transition among various subtypes is responsible for drug resistance in the clinic.In this review,we summarize the recent understanding of lung stem cells in regeneration and tumorigenesis as well as related molecular mechanisms,with the hope to provide helpful insights for clinical treatments of respiratory diseases.

关 键 词：Lung stem cells Lung cancer REGENERATION TUMORIGENESIS Pathological transition 

分 类 号：R734.2[医药卫生—肿瘤]