Regulation of bile acid receptor activity  

作　　者：Yu-Jui Yvonne Wan Lili Sheng 

机构地区：[1]Department of Medical Pathology and Laboratory Medicine,University of California,Davis,Sacramento,CA,USA

出　　处：《Liver Research》2018年第4期180-185,共6页肝脏研究（英文）

基　　金：This study was supported by grants funded by the USA National Institutes of Health(NIH)U01CA179582 and R01 CA222490.

摘　　要：Many receptors can be activated by bile acids(BAs)and their derivatives.These include nuclear receptors farnesoid X receptor(FXR),pregnane X receptor(PXR),and vitamin D receptor(VDR),as well as membrane receptors Takeda G protein receptor 5(TGR5),sphingosine-1-phosphate receptor 2(S1PR2),and cholinergic receptor muscarinic 2(CHRM2).All of them are implicated in the development of metabolic and immunological diseases in response to endobiotic and xenobiotic exposure.Because epigenetic regulation is critical for organisms to adapt to constant environmental changes,this review article summarizes epigenetic regulation as well as post-transcriptional modification of bile acid re-ceptors.In addition,the focus of this review is on the liver and digestive tract although these receptors may have effects on other organs.Those regulatory mechanisms are implicated in the disease process and critically important in uncovering innovative strategy for prevention and treatment of metabolic and immunological diseases.

关 键 词：Bile acid receptor Farnesoid X receptor(FXR) G protein-coupled bile acid receptor Takeda G protein receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) ACETYLATION Methylation GLYCOSYLATION 

分 类 号：R57[医药卫生—消化系统]