Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and contro  

作　　者：Ze-Li Tang Yan Huang Xin-Bing Yu 

机构地区：[1]Department of Parasitology,Zhongshan School of Medicine,Sun Yat-sen University,74 Zhongshan 2nd Road,Guangzhou 510080,People’s Republic of China [2]Key Laboratory for Tropical Diseases Control,Sun Yat-sen University,Ministry of Education,Guangzhou 510080,People’s Republic of China

出　　处：《Infectious Diseases of Poverty》2016年第1期636-647,共12页贫困所致传染病（英文）

基　　金：supported by grants from the National Important Sci-tech Special Projects(No.2012ZX10004220);the Guangdong Natural Science Foundation of China(No.2014A030313027);the Science and Technology Planning Project of Guangdong Province(No.2013B010404010);the National Key Basic Research and Development Project of China(973 project,No.2010CB530000).

摘　　要：Clonorchiasis,caused by Clonorchis sinensis(C.sinensis),is an important food-borne parasitic disease and one of the most common zoonoses.Currently,it is estimated that more than 200 million people are at risk of C.sinensis infection,and over 15 million are infected worldwide.C.sinensis infection is closely related to cholangiocarcinoma(CCA),fibrosis and other human hepatobiliary diseases;thus,clonorchiasis is a serious public health problem in endemic areas.This article reviews the current knowledge regarding the epidemiology,disease burden and treatment of clonorchiasis as well as summarizes the techniques for detecting C.sinensis infection in humans and intermediate hosts and vaccine development against clonorchiasis.Newer data regarding the pathogenesis of clonorchiasis and the genome,transcriptome and secretome of C.sinensis are collected,thus providing perspectives for future studies.These advances in research will aid the development of innovative strategies for the prevention and control of clonorchiasis.

关 键 词：CLONORCHIASIS Clonorchis sinensis Diagnosis PATHOGENESIS OMICS PREVENTION 

分 类 号：R57[医药卫生—消化系统]