Molecular bases of Sorcin-dependent resistance to chemotherapeutic agents  

作　　者：Ilaria Genovese Andrea Ilari Theo Battista Valerio Chiarini Francesco Fazi Annarita Fiorillo Gianni Colotti 

机构地区：[1]Department of Radiology,Oncology and Pathology,Sapienza University of Rome,Rome 00161,Italy. [2]IBPM-CNR,Institute of Molecular Biology and Pathology,Italian National Research Council,Rome 00185,Italy. [3]Department of Biochemical Sciences,Sapienza University of Rome,Rome 00185,Italy. [4]Institute of Biotechnology,University of Helsinki,Helsinki 00014,Finland. [5]Department of Anatomical,Histological,Forensic Medicine&Orthopedic Sciences,Sapienza University of Rome,laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti,Rome 00161,Italy

出　　处：《Cancer Drug Resistance》2018年第3期164-180,共17页癌症耐药（英文）

基　　金：We acknowledge“Quality methods for Design of Experiments in Scientific Research”,in the FaReBio di QualitàProject:Quality and Project Management OpenLab:qPMO CNR;the Flagship Project Nanomax:“NADINE:Nanotechnology-based Diagnostics In Neurological diseases and Experimental oncology”;PRIN 20154JRJPP MIUR;Progetto Ricerca Finalizzata Min.Salute RF-2016-02364123 RAREST‐JHD.

摘　　要：Soluble resistance-related calcium binding protein(Sorcin)is a protein initially labelled“resistance-related”,since it is co-amplified with ABCB1 in multidrug(MD)-resistant cells.While for years Sorcin overproduction was believed to be a by-product of the co-amplification of its gene with the P-glycoprotein gene,many recent studies view Sorcin as an oncoprotein,playing an important role in MD resistance(MDR).Sorcin is one of the most highly expressed calciumbinding proteins,which is overexpressed in many human tumors and MD resistant cancers,and represents a novel MDR marker.Sorcin expression in tumors inversely correlates with patients’response to chemotherapies and overall prognosis.Sorcin is highly expressed in MDR cell lines over their parent cells.Sorcin overexpression by gene transfection increases drug resistance to a variety of chemotherapeutic drugs in many cancer lines.On the other hand,Sorcin silencing leads to reversal of drug resistance in many cell lines.This review describes:(1)the roles of Sorcin in the cell;(2)the studies showing Sorcin overexpression in tumors and cancer cells;(3)the studies showing the effects of Sorcin overexpression and silencing;(4)the molecular effects of Sorcin overexpression;and(5)the structural and genetic bases of Sorcin-dependent MDR.

关 键 词：SORCIN calcium CANCER multidrug resistance in cancer DOXORUBICIN endoplasmic reticulum heart brain ryanodine receptors ER stress 

分 类 号：R73[医药卫生—肿瘤]