The protective effect of a standardized hydroalcoholic extract of Prosopis farcta (Banks & Sol.) J.F.Macbr. fruit in a rat model for experimental ulcerative colitis  

作　　者：Ali Akbar Safari Mohammad Sharifzadeh Gholamreza Hassanzadeh Mohammad-Reza Delnavazi􀏰 Mohammad Mahdi Ahmadian-Attari Amir Hossein Abdolghaffari Maryam Baeeri Mehran Mirabzadeh Ardakani 

机构地区：[1]Department of Traditional Pharmacy,School of Persian Medicine,Tehran University of Medical Sciences,Tehran,Iran [2]Department of Pharmacology and Toxicology,Faculty of Pharmacy,Tehran University of Medical Sciences,Tehran,Iran [3]Department of Anatomy,School of Medicine,Tehran University of Medical Sciences,Tehran,Iran [4]Department of Pharmacognosy,Faculty of Pharmacy,Tehran University of Medical Sciences,Tehran,Iran [5]Evidence-based Phytotherapy and Complementary Medicine Research Center,Alborz University of Medical Sciences,Karaj,Iran [6]Department of Pharmacognosy,Faculty of Pharmacy,Alborz University of Medical Sciences,Karaj,Iran [7]Department of Toxicology&Pharmacology,Faculty of Pharmacy,Tehran Medical Sciences,Islamic Azad University,Tehran,Iran [8]Medicinal Plants Research Center,Institute of Medicinal Plants,ACECR,Tehran,Iran [9]Toxicology and Diseases Group(TDG),Pharmaceutical Sciences Research Center(PSRC),The Institute of Pharmaceutical Sciences(TIPS),Faculty of Pharmacy,Tehran University of Medical Sciences,Tehran,Iran [10]GI Pharmacology Interest Group(GPIG),Universal Scientific Education and Research Network(USERN),Tehran,Iran [11]Pharmaceutical Sciences Research Center,Tehran University of Medical Sciences,Tehran,Iran

出　　处：《Traditional Medicine Research》2021年第5期1-9,共9页TMR传统医学研究

摘　　要：Background:Investigating new therapies for inflammatory bowel disease among natural products has recently been gaining attention.Although Prosopis farcta has repeatedly been mentioned in traditional Persian medicine as a therapeutic option for inflammatory bowel disease,no evidence-based investigations have been conducted on this topic.The aim of this study was to assess the impact of P.farcta on acetic acid-induced colitis in rats.Methods:A hydroalcoholic extract of P.farcta fruits was prepared.Thirty-six adult Wistar rats were divided into six groups,and colitis was induced in five groups,except the sham group,using acetic acid solution.The animals received distinctive daily doses of P.farcta(50,75,and 100 mg/kg/day,p.o.)and dexamethasone(1 mg/kg/day,i.p.)as standard treatment for two progressive days,starting from colitis induction.Microscopic and histopathological examinations were performed on inflamed colonic tissue.Tissue concentrations of interleukin-1βand tumor necrosis factor-αwere assessed using enzyme-linked immunosorbent assay kits.To identify the role of oxidative stress in ulcerative colitis,the levels of malondialdehyde and myeloperoxidase were measured in colon tissues.Results:Treatment with all concentrations of P.farcta attenuated inflammation and ulcers compared with saline treatment in the control group(P<0.01 for 50 mg/kg;P<0.001 for 75 and 100 mg/kg/day).The best suppression of tumor necrosis factor-αand interleukin-1βwas observed at a dose of 100 mg/kg P.farcta(P<0.001).This dose showed the best effect in reducing myeloperoxidase and malondialdehyde in ulcerative colitis-induced rats(P<0.001).Conclusion:P.farcta can be considered a promising candidate for treating ulcerative colitis;thus,it requires further confirmation by clinical trials.

关 键 词：Prosopis farcta COLITIS INTERLEUKIN-1Β tumor necrosis factor MALONDIALDEHYDE traditional Persian medicine 

分 类 号：R57[医药卫生—消化系统]