甲壳类氨基脲的来源及检测方法研究进展  

Research progress on the source and detection method of crustacean semicarbazide

作　　者：张祎 余海霞 陈霞霞[1] 陈雪昌 张小军[3] 严忠雍[3] ZHANG Yi;YU Hai-Xia;CHEN Xia-Xia;CHEN Xue-Chang;ZHANG Xiao-Jun;YAN Zhong-Yong(College of Food and Pharmacy,Zhejiang Ocean University,Zhoushan 316022,China;Ocean Research Center of Zhoushan,Zhejiang University,Zhoushan 316021,China;Zhejiang Marine Fisheries Research Institute,Key Laboratory of Sustainable Utilization of Technology Research for Fishery Resourcesof Zhejiang Province,Zhoushan 316021,China;Ocean College,Zhejiang University,Zhoushan 316021,China)

机构地区：[1]浙江海洋大学食品与药学学院,舟山316022 [2]浙江大学舟山海洋研究中心,舟山316021 [3]浙江省海洋水产研究所,浙江省海洋渔业资源可持续利用技术研究重点实验室,舟山316021 [4]浙江大学海洋学院,舟山316021

出　　处：《食品安全质量检测学报》2021年第16期6301-6309,共9页Journal of Food Safety and Quality

基　　金：国家自然科学基金项目(31901787);浙江省海洋水产研究所自选项目(HYSZX202104)~~。

摘　　要：氨基脲(semicarbazide,SEM)作为呋喃西林的代谢产物,在动物体内能够与蛋白质形成稳定的结合物,难以代谢完全,人体摄入后会产生一些毒理作用。通常以氨基脲为检测目标来判别甲壳类水产品中呋喃西林的使用情况,但根据现有的研究结果发现,除呋喃西林源氨基脲外,其他途径也能产生氨基脲,目前已知的途径包括:环境摄入、加工过程中使用次氯酸钠消毒、偶氮甲酰胺的分解及内源性氨基脲的存在。在目前我国水产贸易中,甲壳类水产品中内源性氨基脲的天然存在为呋喃西林药物检测带来了严重的影响和干扰,致使无法准确地判定氨基脲的来源。因此本文总结了食品中氨基脲的各种可能来源,并介绍了现行的氨基脲检测方法,在此基础上进一步预测了有关内源性氨基脲的可能产生途径,以帮助确定甲壳类水产品中氨基脲的来源途径,从而准确检测氨基脲。Semicarbazide(SEM),as a metabolite of nitrofurazone,can form a stable combination with protein in animal body,which is difficult to metabolize completely,and will produce some toxicological effects after ingestion.Semicarbazide is usually used as the detection target to judge the use of nitrofurazone in crustacean aquatic products.However,according to the existing research results,semicarbazide can be produced by other ways besides semicarbazide from nitrofurazone.Currently,the known ways include environmental intake,disinfection with sodium hypochlorite during processing,decomposition of azoformamide and existence of endogenous semicarbazide.In the current aquatic trade in China,the natural existence of endogenous semicarbazide in crustacean aquatic products has brought serious influence and interference to the detection of nitrofurazone,which makes it impossible to accurately determine the source of semicarbazide.Therefore,this paper summarized various possible sources of semicarbazide in food,and introduced the current detection methods of semicarbazide.On this basis,further predicted the possible production pathways of endogenous semicarbazide,to help determine the source pathways of semicarbazide in crustacean aquatic products and accurately detect semicarbazide.

关 键 词：甲壳类水产品 氨基脲 来源 内源性物质 

分 类 号：TS254.7[轻工技术与工程—水产品加工及贮藏工程]