Macrophages in leukemia microenvironment  

作　　者：Lina Wang Guoguang Zheng 

机构地区：[1]State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,China

出　　处：《Blood Science》2019年第1期29-33,共5页血液科学（英文）

基　　金：supported by grants 81570153 and 81770183 from the National Natural Science Foundation of China(NSFC);programs 2016-I2M-2–006 and 2017-I2M-1–015 from the CAMS Innovation Fund for Medical Sciences(CIFMS);grant 17JCZDJC35000 from the Tianjin Natural Science Foundation;a recipient of the New Century Excellent Talents in University(NCET-08–0329).

摘　　要：Macrophages,the important component of tissue microenvironment,play important roles in both physiological and pathological processes,including tumor and leukemia.Tumor-associated macrophages are involved in tumor proliferation,angiogenesis,invasion,metastasis,and chemotherapy resistance.In leukemia,macrophages are educated by leukemia microenvironment to obtain specific activated phenotype and participate in leukemia progression.Recent studies have shown that accumulation of macrophages in leukemia patients or mouse model is correlated with poor prognosis.Hence,increasing attentions have been paid to study the characteristics of them and to develop novel therapeutic strategies targeting macrophages against leukemia.In this article,we summarize recent development of macrophages in leukemia microenvironment.

关 键 词：HETEROGENEITY Leukemia microenvironment Leukemia-associated macrophages(LAMs) MACROPHAGES Targeting therapy 

分 类 号：R73[医药卫生—肿瘤]