罗伊氏乳杆菌对机体免疫功能调节作用的荟萃分析  

A Meta-analysis of the Regulatory Effect of Lactobacillus reuteri on Immune Function

作　　者：蔡铁全 赵薇 张文羿[1] Cai Tiequan;Zhao Wei;Zhang Wenyi(Key Laboratory of Dairy Biotechnology and Engineering,Ministry of Education,Inner Mongolia Agricultural University,Hohhot 010018;Food Review Center of State Administration for Market Regulation,Beijing 100070)

机构地区：[1]内蒙古农业大学乳品生物技术与工程教育部重点实验室,呼和浩特010018 [2]国家市场监督管理总局食品审评中心,北京100070

出　　处：《中国食品学报》2021年第9期409-415,共7页Journal of Chinese Institute Of Food Science and Technology

基　　金：保健食品原料目录研究专项课题(ZBW-2018-BJ-08)。

摘　　要：目的:通过荟萃分析将国内外近几十年临床上关于罗伊氏乳杆菌对机体的免疫调节作用研究进行汇总,总结该菌对机体免疫功能的调节作用。方法:通过Medline、SCI(Science Citation Index)、万方学术期刊论文数据库、中国知网中国学术期刊网络出版总库、中国生物医学文献数据库等5个数据库进行文献检索。利用Review Manager 5.3纳入随机对照试验数据做统计学分析。P<0.05为有统计学意义。结果:通过检索,6篇参考文献,共计13项随机对照试验被纳入本研究,分析受试者总人数为740人,其中益生菌组378人,安慰剂组362人。在95%置信区间内观察各指标在益生菌组与对照组间的平均差为:TNF-α,-3.09 pg/mL([-4.17,-2.02];P<0.0001);IL-6,-4.49 pg/mL([-7.08,-1.90];P<0.0001);IL-1β,-8.72 pg/mL([-12.53,-4.92];P<0.0001);IL-8,-69.71 pg/mL([-103.84,-35.58];P<0.0001)。结论:罗伊氏乳杆菌对机体免疫功能具有一定的调节作用。Objective:In order to summarize the clinical research on regulatory effect of Lactobacillus reuteri on immunity in recent decades through meta-analysis,and to explore the regulatory effect of L.reuteri on the immune function of organism.Methods:Literature searches were conducted through 5 databases including Medline,SCI,Wan-Fang data,China National Knowledge Infrastructure and Chinese Biological Medical databases.Review Manager version 5.3 was used to organize data and statistical analysis of included randomized controlled trials.A P value less than 0.05 in confidence interval method was considered statistically significant.Results:6 references and 13 RCTs were included in this work after researching.The number of subjects included in the meta-analysis was 740,with 362 for the control group and 378 for the probiotics.Mean differences observed between probiotic-receivers and control at 95%confidence interval:TNF-α,-3.09 pg/mL([-4.17,-2.02];P<0.0001);IL-6,-4.49 pg/mL([-7.08,-1.90];P<0.0001);IL-1β,-8.72 pg/mL([-12.53,-4.92];P<0.0001);IL-8,-69.71 pg/mL([-103.84,-35.58];P<0.0001).Conclusion:L.reuteri has a certain regulatory effect on the subjects'immunity.

关 键 词：罗伊氏乳杆菌 免疫调节 荟萃分析 

分 类 号：TS201.3[轻工技术与工程—食品科学]