A new paradigm for artesunate anticancer function:considerably enhancing the cytotoxicity via conjugating artesunate with aptamer  

作　　者：Yingying Li Yongbo Peng Yan Tan Wenjing Xuan Ting Fu Xue-Qiang Wang Weihong Tan 

机构地区：[1]Molecular Science and Biomedicine Laboratory(MBL),State Key Laboratory of Chemo/Bio-Sensing and Chemometrics,College of Chemistry and Chemical Engineering,College of Biology,Aptamer Engineering Center of Hunan Province,Hunan University,Changsha,PR China [2]Institute of Molecular Medicine(IMM),Renji Hospital,Shanghai Jiao Tong University School of Medicine,and College of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai,PR China [3]The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital),Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,Hangzhou,Zhejiang,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第10期2964-2966,共3页信号转导与靶向治疗（英文）

基　　金：supported by the National Key R&D Project of China(2018YFA0902300);NSFC grants(81602499,21827811,91753109);Hu-Xiang Young Talent Program from Hunan Province(2019RS2022).

摘　　要：Dear Editor,Artemisinin and its derivatives(AIDs)have recently been widely applied in cancer therapy as promising therapeutic agents owing to its hypotoxicity and special bioactivation pathways.Though numerous strategies have been established to improve the potency of AIDs,they are still relatively inefficacious against cancers,especially as a monotherapy.^(1)It is thus essential to develop novel approaches to considerably enhance their anticancer efficacy.We hypothesized that aptamers with specific recognition,high-affinity binding,and receptor-mediated internalization would promote the accumulation of AIDs inside the target cells and lead to death of the target cancer cells.^(2)

关 键 词：ARTESUNATE considerably CYTOTOXICITY 

分 类 号：R730.5[医药卫生—肿瘤]