Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters  

作　　者：Wei Huang Ming-Liang Han Yu-Wen Liu Hui Xu Hui-Xiong Dai 

机构地区：[1]School of Pharmacy,Nanchang University,Nanchang 330006,China [2]b Chinese Academy of Sciences Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica,Shanghai 201203,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]Institute for Advanced Study,Shenzhen University,Shenzhen 518060,China [5]Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,College of Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China

出　　处：《Chinese Chemical Letters》2021年第9期2765-2768,共4页中国化学快报（英文版）

基　　金：the Shanghai Institute of Materia Medica;the Chinese Academy of Sciences;the National Natural Science Foundation of China(Nos.21772211 and 21920102003);the Youth Innovation Promotion Association CAS(Nos.2014229 and 2018293);the Science and Technology Commission of Shanghai Municipality(Nos.17JC1405000 and 18431907100);the Program of Shanghai Academic Research Leader(No.19XD1424600);the National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”,China(No.2018ZX09711002-006)for financial support。

摘　　要：We report herein a palladium-catalyzed diarylative dearomatization of indole by employing thioester and arylboronic acid as the aryl electrophiles.The reaction involved a decarbonylation/migratory insertion/terminal Suzuki coupling procedure.Substrates bearing various functional groups are well tolerated in the reaction,affording the diarylated indoline skeletons in moderate to good yields.

关 键 词：THIOESTER DECARBONYLATION DEAROMATIZATION Indolines skeleton Diarylation 

分 类 号：O621.251[理学—有机化学]