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supported by the National Natural Science Foundation of China(22125101,22331002 to H.L.,22171037,22101040 to W.R.)。
Polythiourethanes(PTU)and polythioesters(PTE)derived from renewable sources are emerging sustainable polymers for their excellent degradability and recyclability.However,P(TU-alt-TE)copolymers have been rare and chall...
supported by the National Science Fund for Distinguished Young Scholars(22225701);the Interdisciplinary Program of Shanghai Jiao Tong University(20230102);the National Natural Science Foundation of China(22077080,92253302 and 22275122);the Shanghai Pilot Program for Basic Research Shanghai Jiao Tong University(21TQ1400210);the Special Projects of the Central Government in Guidance of Local Science and Technology Development(2021Szvup077);the China Post-doctoral Science Foundation(2023M732214).
Expressed protein ligation(EPL)provides a powerful tool to access large-size proteins with precise structures.Existing methods for constructing the critical protein thioester for EPL have predominantly relied on the r...
supported by the National Key R&D Program of China(2021YFA1501700);the National Natural Science Foundation of China(51903177,U19A2095);the“1000-Youth Talents Program”;the Fundamental Research Funds for the Central Universities(YJ201924,YJ202209)。
Developing new chemically recyclable polymers is important for a circular plastics economy.Herein,we prepared a class of 1,4-dithian-2-one(DTO)with thioether and thioester functionalities.These sulfur-substituted mono...
We thank the financial supports from the Natural Science Foundationof Zhejiang Province(LY21B020010).
A general and straightforward strategy for the synthesis of thioester-substituted oxindoles via a palladium-catalyzed thiocarbonyla-tive cyclization process has been developed.With sulfonyl chlorides as promising sulf...
the Shanghai Institute of Materia Medica;the Chinese Academy of Sciences;the National Natural Science Foundation of China(Nos.21772211 and 21920102003);the Youth Innovation Promotion Association CAS(Nos.2014229 and 2018293);the Science and Technology Commission of Shanghai Municipality(Nos.17JC1405000 and 18431907100);the Program of Shanghai Academic Research Leader(No.19XD1424600);the National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”,China(No.2018ZX09711002-006)for financial support。
We report herein a palladium-catalyzed diarylative dearomatization of indole by employing thioester and arylboronic acid as the aryl electrophiles.The reaction involved a decarbonylation/migratory insertion/terminal S...
Supported by the Fundamental Research Funds for the Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, China(No.130028652), the Natural Science Foundation of Liaoning Province, China(No.201602002), the Foundation of Liaoning Province Education Administration, China(No.L2015003) and the National Natural Science Foundation of China(No.20902010).
A FeCl3-6H2O-catalyzed synthesis of β-ketothioesters from the hydrolysis reaction of chain α-oxoketene dithioacetals was carried out. Subsequently, we explored the FeCl3-6H2O-catalyzed Friedel-Crafts alkylation of t...
supported by the Peking University Health Science Center(BMU20130354);State Key Laboratory of Natural and Biomimetic Drugs,the National Recruitment Program of Global Youth Experts(1000 Plan);the National Natural Science Foundation of China (21502005)
Solid phase peptide synthesis(SPPS)based on Fmoc chemistry has become a commonly used technique in peptide chemistry,as it can be easily conducted using automated machine,and not requiring highly toxic HF in compariso...
A new series of copoly(ester-thioester)s had been synthesized using direct polycondensation technique. These copolythioesters were synthesized by direct polycondensation of 4,4'-(tereph-thaloyIdithio) diacetic acid I,...
NSFC (No. 21202006);FRFCU (No. FRF-TP14-015A2) for financial supports and Super-computer Center of Shanghai and Shenzhen for technical supports
As the rate-determining step in native chemical ligation reactions, the thiol–thioester exchange step is important in determining the efficiency of the ligations of peptides. In the present study, systematic theoreti...
Amphipathic-type thioesters CH3(CH2)mCOS(CH2)nCOONa (m + n = 12) were synthesized and their reaction with various alkylamines was examined. Compounds having thioester moiety close to carboxylate (m = 10, n = 2) afford...