纳米结构酶催化剂研究进展  

Advances in nanostructured enzyme catalysts

作　　者：夏欢 卢滇楠[2] 戈钧 吴建中[3] 刘铮 XIA Huan;LU Diannan;GE Jun;WU Jianzhong;LIU Zheng(Tsinghua Shenzhen International Graduate School,Shenzhen 518055,Guangdong,China;Department of Chemical Engineering,Tsinghua University,Beijing 100084,China;Department of Chemical and Environmental Engineering,University of California,Riverside 92521,California,USA)

机构地区：[1]清华大学深圳国际研究生院,广东深圳518055 [2]清华大学化学工程系,北京100084 [3]加州大学河滨分校化学与环境工程系,美国加利福尼亚92521

出　　处：《化工学报》2021年第12期6086-6092,共7页CIESC Journal

基　　金：国家自然科学基金项目(21878174)。

摘　　要：将酶负载于载体上可以提高工业应用中酶的稳定性并便于重复使用。纳米材料的发展为固定化酶提供了新的契机,利用纳米材料固定化酶有望进一步提高酶在工业环境中的催化性能、拓展固定化酶的应用范围。本文主要关注近年来在纳米结构酶催化剂方面的研究进展,重点介绍本研究组以无机晶体、金属有机骨架材料、石墨烯和功能高分子等为载体进行酶固定化以及酶催化过程多尺度分子模拟方法的研究进展,讨论了纳米结构酶催化剂的发展前景。Loading the enzyme on the carrier can improve the stability of the enzyme in industrial applications and facilitate repeated use. Utilizing nanostructured materials for enzyme immobilization has offered unprecedented opportunities in enhancing enzyme stability in adverse conditions found in industrial practices and thus extending the application spectra of enzymatic catalysis. This review summarizes recent progress of our group in exploring nanostructured enzyme catalysts using inorganic crystals, metal-organic frameworks, graphene and environmentally responsive polymers as matrixes, as well as a new molecular simulation method that combines with Markov-state modeling for establishing a process profile with molecular insight. The prospects of the nanostructured enzyme catalysts are also discussed.

关 键 词：固定化酶 纳米材料 生物催化 酶催化 

分 类 号：TQ028.8[化学工程]