Circ-ADAM9:a novel biomarker in human cancers  

作　　者：Melika Amelimojarad Mandana AmeliMojarad 

机构地区：[1]Department of Molecular Biology,Kharazmi University,Iran

出　　处：《Cancer Advances》2022年第1期1-4,共4页TMR肿瘤进展

摘　　要：Circular RNAs(CircRNA)were recently found as a closed continuous loop subset of competing endogenous RNAs,with an ability to control gene expression by microRNA sponging.There are many studies on circRNAs potential roles in cancer development.lately;studies have described the important roles of CircRNAs in cancers,indicating their oncogene role to promote cancer or as a tumor suppressor to decrease the diseases.Recently discovered CircRNA adam9 has been suggested to be involved in multiple physiological and pathological processes including cancer.With this aspect,aberrant expression of Circ-ADAM9 has been shown in a variety of human malignancies,suggesting an important role for Circ-adam9 in tumor genesis.This review summarizes the recent discoveries done on the role of circ-adam9 in different cancers and discusses its potential prognostic,diagnostic,and therapeutic values as a novel biomarker.

关 键 词：Circ-ADAM9 CANCER target gene ONCOGENE 

分 类 号：R73[医药卫生—肿瘤]