Issues of origin,morphology and clinical significance of tumor microvessels in gastric cancer  

作　　者：Marina A Senchukova 

机构地区：[1]Department of Oncology,Orenburg State Medical University,Orenburg 460021,Russia

出　　处：《World Journal of Gastroenterology》2021年第48期8262-8282,共21页世界胃肠病学杂志（英文版）

摘　　要：Gastric cancer(GC)remains a serious oncological problem,ranking third in the structure of mortality from malignant neoplasms.Improving treatment outcomes for this pathology largely depends on understanding the pathogenesis and biological characteristics of GC,including the identification and characterization of diagnostic,prognostic,predictive,and therapeutic biomarkers.It is known that the main cause of death from malignant neoplasms and GC,in particular,is tumor metastasis.Given that angiogenesis is a critical process for tumor growth and metastasis,it is now considered an important marker of disease prognosis and sensitivity to anticancer therapy.In the presented review,modern concepts of the mechanisms of tumor vessel formation and the peculiarities of their morphology are considered;data on numerous factors influencing the formation of tumor microvessels and their role in GC progression are summarized;and various approaches to the classification of tumor vessels,as well as the methods for assessing angiogenesis activity in a tumor,are highlighted.Here,results from studies on the prognostic and predictive significance of tumor microvessels in GC are also discussed,and a new classification of tumor microvessels in GC,based on their morphology and clinical significance,is proposed for consideration.

关 键 词：Gastric cancer ANGIOGENESIS Tumor microvessels Vascular endothelial growth factor HYPOXIA Prognosis 

分 类 号：R735.2[医药卫生—肿瘤]