Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G_(s)  

作　　者：Lu Xu Bo Chen Hannes Schihada Shane C.Wright Ainoleena Turku Yiran Wu Gye-Won Han Maria Kowalski-Jahn Pawel Kozielewicz Carl-Fredrik Bowin Xianjun Zhang Chao Li Michel Bouvier Gunnar Schulte Fei Xu 

机构地区：[1]iHuman Institute,ShanghaiTech University,Shanghai,China [2]School of Life Science and Technology,ShanghaiTech University,Shanghai,China [3]Center for Excellence in Molecular Cell Science,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,China [4]University of Chinese Academy of Sciences,Beijing,China [5]Section of Receptor Biology&Signaling,Department of Physiology&Pharmacology,Karolinska Institutet,Stockholm,Sweden [6]Institute for Research in Immunology and Cancer,Department of Biochemistry and Molecular Medicine,Universitéde Montréal,Montréal,QC,Canada [7]Departments of Biological Sciences and Chemistry,Bridge Institute,University of Southern California,Los Angeles,CA,USA [8]Present address:Orion Pharma R&D,Espoo,Finland

出　　处：《Cell Research》2021年第12期1311-1314,共4页细胞研究（英文版）

基　　金：This work was supported by the National Key R&D Program of China(2018YFA0507000 to F.X.);the National Natural Science Foundation of China(32071194 to F.X.);Work at Karolinska Institutet was supported by Karolinska Institutet,the Swedish Research Council(2017-04676;2019-01190);the Swedish Cancer Society(CAN2017/561,201102 PjF,200264P);the Novo Nordisk Foundation(NNF17OC0026940;NNF20OC0063168);The Swedish Society of Medical Research(SSMF;P19-0055);the Lars Hierta Memorial Foundation(FO2019-0086,FO2020-0304);The Alex and Eva Wallström Foundation for Scientific Research and Education(2020-00228);the German Research Foundation(DFG,427840891,KO 5463/1-1).S.C.W.is supported by a fellowship from the Swedish Society for Medical Research(P18-0098);Computational resources were provided by the Swedish National Infrastructure for Computing(SNIC 2020/5-500).M.B.is funded by the CIHR(FDN-148431);holds a Canada Research Chair in Signal Transduction and Molecular Pharmacology.

摘　　要：Dear Editor,The ten mammalian Frizzleds(FZD1–10)belong to the class F of G protein-coupled receptors(GPCRs)and mediate WNT signaling through interaction with transducer proteins including Dishevelled(DVL)or heterotrimeric G proteins.1 Their involvement in human disease has put FZDs at the forefront of drug targets,especially anti-cancer therapy.

关 键 词：INVOLVEMENT CONSTITUTIVE FRIZZLED 

分 类 号：R730.5[医药卫生—肿瘤]