红曲的化学成分、药理作用及临床应用研究进展  

Research progress on chemical constituents,pharmacological action and clinical application of Fermentum Rubrum

作　　者：蒋沅岐 董玉洁 周福军[2,3,4] 陈金鹏 周钰通 田成旺 陈常青[2,3,4] JIANG Yuan-qi;DONG Yu-jie;ZHOU Fu-jun;CHEN Jin-peng;ZHOU Yu-tong;TIAN Cheng-wang;CHEN Chang-qing(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300462,China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine,Tianjin 300462,China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin 300462,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津药物研究院,天津300462 [3]天津市中药质量标志物重点实验室,天津300462 [4]释药技术与药代动力学国家重点实验室,天津300462

出　　处：《中草药》2021年第23期7379-7388,共10页Chinese Traditional and Herbal Drugs

基　　金：国家重大新药创制专项(2019ZX09201005-001-002);国家中医药管理局中药国际化专项(0610-2040NF020928)。

摘　　要：红曲为大米接种红曲菌发酵而成,能产生莫纳可林类、甾醇类、红曲色素等多种代谢产物,具有调脂、抗肿瘤、抗氧化、抗糖尿病等生物活性,广泛应用于医药、食品添加剂、发酵食品、生物催化等领域。主要综述了国内外红曲的化学成分、药理作用及临床应用的研究进展,以期为红曲进一步的应用与开发提供参考。Hongqu(Fermentum Rubrum)is fermented from rice inoculated with monascus fungus,and it can produce many kinds of metabolites such as monacolins,sterols and monascus pigment.It has lipid-regulating,antitumor,antioxidant,antidiabetic effects and other biological activities,and is widely used in medicine,food additives,fermented food,biocatalysis and other fields.Research progress on chemical constituents,pharmacological action and clinical application of Fermentum Rubrum were summarized in this paper,in order to provide reference for further application and development of Fermentum Rubrum.

关 键 词：红曲 莫纳可林K 麦角甾醇 豆甾醇 红曲色素 调脂 抗肿瘤 抗氧化 

分 类 号：R282.710.5[医药卫生—中药学]