Natural products:potential treatments for cisplatin-induced nephrotoxicity  

作　　者：Chun-yan Fang Da-yong Lou Li-qin Zhou Jin-cheng Wang Bo Yang Qiao-jun He Jia-jia Wang Qin-jie Weng 

机构地区：[1]Center for Drug Safety Evaluation and Research,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Medication Department,Zhuji People’s Hospital of Zhejiang Province,Zhuji 311800,China

出　　处：《Acta Pharmacologica Sinica》2021年第12期1951-1969,共19页中国药理学报（英文版）

基　　金：supported by the State Key Program of National Natural Science Foundation of China(No.81872878);a grant from Zhejiang Provincial Natural Science Foundation(No.LGF20H030001).

摘　　要：Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies,such as head and neck,lung,testis,ovary,breast cancer,etc.However,it has only a limited use in clinical practice due to its severe adverse effects,particularly nephrotoxicity;20%-35% of patients develop acute kidney injury(AKI)after cisplatin administration.The nephrotoxic effect of cisplatin is cumulative and dose dependent and often necessitates dose reduction or withdrawal.Recurrent episodes of AKI result in impaired renal tubular function and acute renal failure,chronic kidney disease,uremia,and hypertensive nephropathy.The pathophysiology of cisplatin-induced AKI involves proximal tubular injury,apoptosis,oxidative stress,inflammation,and vascular injury in the kidneys.At present,there are no effective drugs or methods for cisplatin-induced kidney injury.Recent in vitro and in vivo studies show that numerous natural products(flavonoids,saponins,alkaloids,polysaccharide,phenylpropanoids,etc.)have specific antioxidant,anti-inflammatory,and anti-apoptotic properties that regulate the pathways associated with cisplatin-induced kidney damage.In this review we describe the molecular mechanisms of cisplatin-induced nephrotoxicity and summarize recent findings in the field of natural products that undermine these mechanisms to protect against cisplatin-induced kidney damage and provide potential strategies for AKI treatment.

关 键 词：natural products CISPLATIN acute kidney injury NEPHROTOXICITY antioxidant ANTI-INFLAMMATION ANTI-APOPTOSIS NEPHROPROTECTION 

分 类 号：R692[医药卫生—泌尿科学]