Article Navigation Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis  

作　　者：McKay Mullen Fengrui Yang Jun Cao Yang Cao Xu Liu Gee Young Lee Tao Li William Yao Zhihong Yang Jiahai Zhang Kela Johnson Felix Aikhionbare Yong Chen Xinjiao Gao Dongmei Wang Xia Ding Hadiyah-Nicole Green Xing Liu Xuebiao Yao 

机构地区：[1]MOE Key Laboratory for Cellular Dynamics,Anhui Key Laboratory for Chemical Biology,CAS Center for Excellence in Molecular Cell Science,University of Science and Technology of China,Hefei 230027,China [2]Keck Center for Oganoids Plasticity,Morehouse School of Medicine,Atlanta,GA 30310,USA [3]Department of Hepatobiliary Surgery,Xijing Hospital,Xi’an 710032,China [4]BUCM-USTC Collaborative Center for Parietal Cell Research,Beijing University of Chinese Medicine,Beijing 100029,China [5]Ora Lee Smith Cancer Research Foundation,Atlanta,GA 30310,USA

出　　处：《Journal of Molecular Cell Biology》2021年第11期834-837,共4页分子细胞生物学报（英文版）

基　　金：supported by grants from the Ministry of Science and Technology of China(MOST,2017YFA0503600);the National Natural Science Foundation of China(NSFC,81630080,31621002,32090040,21922706,91854203,and 91853115);China Postdoctoral Science Foundation grant(2019M662181);the US National Institutes of Health(NIH,DK56292,DK115812,S21MD000101,and CA164133).

摘　　要：Dear Editor,The hallmarks of cancer comprise several distinct biological characteristics acquired during the multistep development of human tumors with the unique feature of genomic instability(Shen,2011).These cancer characteristics include sustaining proliferative signaling,evading growth suppressors,resisting cell death,enabling replicative immortality,inducing angiogenesis,and activating invasion and metastasis(Chen et al.,2011;Song et al.,2018).Triple-negative breast cancer(TNBC),an aggressive disease with increased risks for visceral metastases,has a poor prognosis due to unavailable and viable therapeutic targets(Bianchini et al.,2016).A TNBC diagnosis indicates that cancer cells test negative for three key receptors:estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2(Bianchini et al.,2016).The absence of these three receptors renders existing hormone and targeted therapies ineffective.

关 键 词：METASTASIS BREAST 

分 类 号：R730.7[医药卫生—肿瘤]