The gut-cardiovascular connection: new era for cardiovascular therapy  

作　　者：Chak Kwong Cheng Yu Huang 

机构地区：[1]School of Biomedical Sciences and Li Ka Shing Institute of Health Science [2]The Chinese University of Hong Kong,Hong Kong SAR 999077,China [3]Heart and Vascular Institute and Shenzhen Research Institute,The Chinese University of Hong Kong,Hong Kong SAR 999077,China

出　　处：《Medical Review》2021年第1期23-46,共24页医学评论（英文）

基　　金：supported by Hong Kong RGC-Senior Research Fellow Scheme(SRFS2021-4S04);National Natural Science Foundation of China(91939302).

摘　　要：Our gut microbiome is constituted by trillions of microorganisms including bacteria,archaea and eukaryotic microbes.Nowadays,gut microbiome has been gradually recognized as a new organ system that systemically and biochemically interact with the host.Accumulating evidence suggests that the imbalanced gut microbiome contributes to the dysregulation of immune system and the disruption of cardiovascular homeostasis.Specific microbiome profiles and altered intestinal permeability are often observed in the pathophysiology of cardiovascular diseases.Gut-derived metabolites,toxins,peptides and immune cell-derived cytokines play pivotal roles in the induction of inflammation and the pathogenesis of dysfunction of heart and vasculature.Impaired crosstalk between gut microbiome and multiple organ systems,such as gut-vascular,heart-gut,gut-liver and brain-gut axes,are associated with higher cardiovascular risks.Medications and strategies that restore healthy gut microbiome might therefore represent novel therapeutic options to lower the incidence of cardiovascular and metabolic disorders.

关 键 词：cardiovascular diseases DYSBIOSIS ENDOTHELIUM ENDOTOXIN fecal microbiota transplantation gut microbiome. 

分 类 号：R57[医药卫生—消化系统]