Exploiting Caenorhabditis elegans to discover human gut microbiota-mediated intervention strategies in protein conformational diseases  

作　　者：Daniel M.Czyż 

机构地区：[1]Department of Microbiology and Cell Science,University of Florida,Gainesville,FL,USA

出　　处：《Neural Regeneration Research》2022年第10期2203-2204,共2页中国神经再生研究（英文版）

基　　金：supported by The National Institutes of Health(R03AG069056-02,R03AG070580-01);Infectious Diseases Society of America(to DMC).

摘　　要：Age-dependent protein-conformational diseases(PCDs),such as Alzheimer’s disease(AD),Parkinson’s disease(PD),or amyotrophic lateral sclerosis(ALS),are characterized by misfolding and aggregation of metastable proteins present within the proteome of the affected individual.Recent evidence supports the notion that bacteria and bacterial products may be affecting the stability of these culprit host proteins and therefore influence disease progression and perhaps even its onset.Although specific culprit proteins are associated with each disease(e.g.,Aβin AD,α-synuclein in PD,and TDP-43 in ALS),bacteria found to affect these diseases do not seem to differentiate between these specific proteins but likely affect host proteostasis in general,leading to misfolding of metastable proteins encoded within the proteome.The evidence that supports this hypothesis comes from studies where a single bacterial genus was linked to multiple PCDs.For example,a decrease in Prevotella spp.is linked to constipation,a condition that precedes PD motor symptoms by as much as 20 or more years(Savica et al.,2009;Zhu et al.,2014).

关 键 词：DISEASES ALZHEIMER FOLDING 

分 类 号：R741[医药卫生—神经病学与精神病学]