The role of HBD-2,HBD-3,and calprotectin in the relationship between chronic periodontitis and atherosclerosis  

作　　者：MEHMET TASPINAR ALIHAN BOZOGLAN ABDULLAH SECKIN ERTUGRUL LEVENT ELMAS 

机构地区：[1]Faculty of Medicine,Aksaray University,Aksaray,Turkey [2]Faculty of Medicine,Yuzuncu Yil University,Van,Turkey [3]Department of Periodontology,Faculty of Dentistry,Fırat University,Elazığ,Turkey [4]Department of Periodontology,Faculty of Dentistry,Yuzuncu Yil University,Van,Turkey [5]Department of Periodontology,Faculty of Dentistry,İzmir KatipÇelebi University,İzmir,Turkey [6]Faculty of Medicine,Pamukkale University,Denizli,Turkey

出　　处：《BIOCELL》2020年第3期337-344,共8页生物细胞（英文）

摘　　要：This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins(HBD)HBD-2,HBD-3,and calprotectin.Atherosclerosis is the most frequently observed cardiovascular disease.Dental and periodontal infections are known to provide a considerable basis for atheroma plaque formation.The study group consists of a total number of 40 subjects,with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic periodontitis.Clinical periodontal and blood parameters and HBD-2,HBD-3,and calprotectin biomarkers in the gingival crevicular fluid were measured.In both groups,following clinical periodontal treatment,a statistically significant decrease in white blood cells(WBC),low-density lipoproteins(LDL),fibrinogen,creatinine,and platelets(PLT),a statistically significant increase in high-density lipoproteins(HDL)in blood samples,statistically meaningful decrease in HBD-2,HBD-3,and calprotectin in the gingival crevicular fluid were achieved.Blood values and HBD-2,HBD-3,calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared to the control group.A positive correlation was observed between decreases in HBD-2,HBD-3,calprotectin,and clinical periodontal indices.Regression in systemic inflammation was observed after clinical periodontal treatment.It is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.

关 键 词：ATHEROSCLEROSIS PERIODONTAL DISEASES HBD-2 HBD-3 CALPROTECTIN 

分 类 号：R78[医药卫生—口腔医学]