SATB2:A versatile transcriptional regulator of craniofacial and skeleton development,neurogenesis and tumorigenesis,and its applications in regenerative medicine  

作　　者：Xia Huang Qiuman Chen Wenping Luo Mikhail Pakvasa Yuxin Zhang Liwen Zheng Shuang Li Zhuohui Yang Huan Zeng Fang Liang Fugui Zhang Daniel A.Hu Kevin H.Qin Eric J.Wang David S.Qin Russell R.Reid Tong-Chuan He Aravind Athiviraham Mostafa El Dafrawy Hongmei Zhang 

机构地区：[1]Stomatological Hospital of Chongqing Medical University,Chongqing 401147,PR China [2]Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,Chongqing 401147,PR China [3]Molecular Oncology Laboratory,Department of Orthopaedic Surgery and Rehabilitation Medicine,The University of Chicago Medical Center,Chicago,IL 60637,USA [4]The Pritzker School of Medicine,The University of Chicago Medical Center,Chicago,IL 60637,USA [5]Department of Surgery,The University of Chicago Medical Center,Chicago,IL 60637,USA [6]Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing 401147,PR China

出　　处：《Genes & Diseases》2022年第1期95-107,I0005,共14页基因与疾病（英文）

基　　金：This reported work was supported in part by research grants from the National Natural Science Foundation of China(No.#81870758 to HZ);Chongqing Research Program of Basic Research and Frontier Technology(No.#cstc2017jcyjAX0020 to HZ).

摘　　要：SATB2(special AT-rich sequence-binding protein 2)is a member of the special AT-rich binding protein family.As a transcription regulator,SATB2 mainly integrates higher-order chromatin organization.SATB2 expression appears to be tissue-and stage-specific,and is governed by several cellular signaling molecules and mediators.Expressed in branchial arches and osteoblast-lineage cells,SATB2 plays a significant role in craniofacial pattern and skeleton development.In addition to regulating osteogenic differentiation,SATB2 also displays versatile functions in neural development and cancer progression.As an osteoinductive factor,SATB2 holds great promise in improving bone regeneration toward bone defect repair.In this review,we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development,neurogenesis,tumorigenesis and regenerative medicine.

关 键 词：Bone regeneration DEVELOPMENT NEUROGENESIS SATB2 TUMORIGENESIS 

分 类 号：R78[医药卫生—口腔医学]