The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline  

作　　者：Amsha S.Alsegiani Zahoor A.Shah 

机构地区：[1]Department of Medicinal and Biological Chemistry,College of Pharmacy and Pharmaceutical Sciences,University of Toledo,Toledo,OH,USA

出　　处：《Neural Regeneration Research》2022年第11期2407-2412,共6页中国神经再生研究（英文版）

基　　金：the College of Pharmacy,Department of Pharmaceutical Chemistry,King Saud University,Riyadh,Saudi Arabia;partly the grants from The American Heart Association,No.17AIREA33700076/ZAS/2017;the National Institute of Neurological Disorders and Stroke of the National Institutes of Health,No.R01NS112642(to ZAS)。

摘　　要：Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attra cted significant attention.Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders.Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases.Maintaining a healthy gut microbiota is essential for a healthy body and aging,but dys biosis could initiate many chro nic diseases.Understanding the underlying mechanisms of gut microbiota alterations/dys biosis will help identify biomarkers for aging-related chro nic conditions.This review summarizes recent advances in micro biota-neurodegenerative disease research and will enhance our unde rstanding of gut microbiota dys biosis and its effects on brain aging.

关 键 词：brain aging cognitive decline DYSBIOSIS fecal microbiota transplantation gut-microbiota NEUROINFLAMMATION PREBIOTICS PROBIOTICS 

分 类 号：R741[医药卫生—神经病学与精神病学]