Emerging mechanisms of immunotherapy resistance in sarcomas  

作　　者：Vaia Florou Breelyn A.Wilky 

机构地区：[1]Department of Medicine,Huntsman Cancer Institute at University of Utah,Salt Lake City,UT 84112,USA [2]Department of Medicine,University of Colorado School of Medicine,Aurora,CO 80045,USA

出　　处：《Cancer Drug Resistance》2022年第1期199-213,共15页癌症耐药（英文）

摘　　要：Sarcomas are a heterogeneous group of over 150 mesenchymal neoplasms of bone and soft tissue.Clinical prognosis remains poor in the metastatic and refractory setting,despite treatment with traditional chemotherapies.A subset of sarcoma patients can exhibit remarkable responses to novel immune therapies;however,most patients will not respond.Emerging data from genetic and transcriptomic datasets suggests that patients who are resistant to checkpoint inhibitor monotherapy may have low expression of immune-related genes,suggesting that the sarcoma was not sufficiently immunogenic to trigger or maintain an immune response to generate tumor-specific immune effector cells.In this review,we discuss the emerging data surrounding potential mechanisms of resistance,including various biomarkers explored in clinical trials of immune therapy for sarcomas.We also review future directions in clinical trials that are focused on boosting tumor immunogenicity to improve the activity of checkpoint inhibitors,as well as adoptive cellular therapy approaches to bypass deficiencies in neoantigens or antigen presentation.

关 键 词：SARCOMA immune therapy immune resistance IMMUNOGENICITY CHEMOTHERAPY clinical trials 

分 类 号：R73[医药卫生—肿瘤]