Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging  

作　　者：Xiuli Chen Feng Liu Bin Chen Haiying Wu Kun Li Yongmei Xie Weihong Kuang Zhihui Li 

机构地区：[1]Department of Thyroid Surgery,West China Hospital of Sichuan University,Chengdu 610041,China [2]Department of Obstetrics,Henan Provincial People’s Hospital,People’s Hospital of Zhengzhou University,Zhengzhou 450003,China [3]Laboratory of Thyroid and Parathyroid Disease,Frontiers Science Center for Disease-related Molecular Network,Rare Diseases Center,West China Hospital of Sichuan University,Chengdu 610041,China [4]Department of Psychiatry and National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Frontiers of Chemical Science and Engineering》2022年第1期112-120,共9页化学科学与工程前沿（英文版）

基　　金：supported by Science and Technology Department of Sichuan Province(Nos.2020YJ0237,2018SZ0030,2019YFH0119);National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(Z20191006);the 135 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYJC18025 and ZYJC18003).

摘　　要：The design of three novel fatty nitrogen mustard-based anticancer agents with fluorophores incorporated into the alkene structure(CXL 118,CXL121,and CXL122)is described in this report.The results indicated that these compounds are selectively located in lysosomes and exhibit effective antitumour activity.Notably,these compounds can directly serve as both reporting and imaging agents in vitro and in vivo without the need to add other fluorescent tagging agents.

关 键 词：fluorescent drug LYSOSOMAL ANTICANCER ZEBRAFISH nude-mouse tumour imaging 

分 类 号：O62[理学—有机化学]