Identification of key genes underlying the effects of obesity on knee osteoarthritis  

作　　者：Siming Dai Juan Zhang Xiaoying Zhu Yuxuan Lin Ying Cui Zhiyi Zhang Zhiguo Lin 

机构地区：[1]Department of Rheumatology,First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001,China

出　　处：《Chinese Medical Journal》2022年第4期474-476,共3页中华医学杂志（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(Nos.81771749 and 81901638);Harbin Technology Bureau Research Fund(No.2017RAQXJ196);Scientific Research Innovation Foundation of the First Affiliated Hospital of Harbin Medical University(No.2019B18)。

摘　　要：To the Editor:Osteoarthritis(OA)is a disease associated with high morbidity and disability.Obesity,typically measured as a body mass index(BMI)≥30 kg/m2,is a well-known risk factor for the onset of OA and its related complications.[1]Interestingly,these two diseases may have common underlying mechanisms which contribute to the pathogenesis,such as genetic changes,and these mechanisms have not yet been fully explored.Gene expression profiling is a powerful tool used to systematically identify the molecular features underlying genetic variations associated with complex multifactorial diseases such as OA.In addition,it has been shown the significance of gene expression in understanding the mechanisms in the pathogenesis of obesity and OA.[2]This study hypothesized that hub genes could explain the relationship between obesity and OA.Consequently,identifying that these genes are involved could provide insights into the detailed regulatory mechanisms of obesity on OA.

关 键 词：OBESITY DISEASES PATHOGENESIS 

分 类 号：R589.2[医药卫生—内分泌] R684.3[医药卫生—内科学]