Infantile hepatic hemangiomas:looking backwards and forwards  

作　　者：Xue Gong Yanan Li Kaiying Yang Siyuan Chen Yi Ji 

机构地区：[1]Division of Oncology,Department of Pediatric Surgery,West China Hospital of Sichuan University,Chengdu 610041,China [2]Pediatric Intensive Care Unit,Department of Critical Care Medicine,West China Hospital of Sichuan University,Chengdu 610041,China

出　　处：《Precision Clinical Medicine》2022年第1期34-45,共12页精准临床医学（英文）

基　　金：This work was supported by the Project of‘0 to 1’of Sichuan University(grant No.2022SCUH0033);the 1·3·5 Project for Disciplines of Excellence Clinical Research Incubation Project,West China Hospital of Sichuan University(grant Nos.2019HXFH056,2020HXFH048,and ZYJC21060).

摘　　要：Infantile hepatic hemangiomas(IHHs)are common benign tumors seen in the liver of infants.IHHs are true infantile hemangiomas(IHs)and have phases of proliferation and involution parallel to those of cutaneous IHs.The definition and classification of IHH are still confusing in the literature.The mechanisms during the pathogenesis of IHH have yet to be discovered.The clinical manifestations of IHH are heterogeneous.Although most IHH lesions are asymptomatic,some lesions can lead to severe complications,such as hypothyroidism,consumptive coagulopathy,and high-output congestive cardiac failure.Consequently,some patients can possibly encounter a fatal clinical condition.The heterogeneity of the lesions and the occurrence of disease-related comorbidities can make the treatment of IHH challenging.Oral propranolol is emerging as an effective systemic approach to IHH with obvious responses in tumor remission and symptom regression.However,the precise clinical characteristics and treatment strategies for patients with severe IHH have not yet beenwell established.Here,we summarize the epidemiology,pathogenicmechanism,clinical manifestations,diagnosis,and treatment of IHH.Recent updates and future perspectives for IHH will also be elaborated.

关 键 词：infantile hepatic hemangioma angiogenesis VASCULOGENESIS screening endothelial progenitor cells GLYCOLYSIS consumptive hypothyroidism treatment 

分 类 号：R73[医药卫生—肿瘤]