Pathological,molecular,and clinical characteristics of cholangiocarcinoma:A comprehensive review  

作　　者：Mukul Vij Yogesh Puri Ashwin Rammohan Gowripriya G Rajesh Rajalingam Ilankumaran Kaliamoorthy Mohamed Rela 

机构地区：[1]Department of Pathology,Dr Rela Institute and Medical center,Chennai 600044,Tamil Nadu,India [2]Institute of Liver Disease and Transplantation,Dr Rela Institute and Medical Center,Chennai 600044,Tamil Nadu,India

出　　处：《World Journal of Gastrointestinal Oncology》2022年第3期607-627,共21页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：Cholangiocarcinomas are a heterogeneous group of highly aggressive cancers that may arise anywhere within the biliary tree.There is a wide geographical variation with regards to its incidence,and risk-factor associations which may include liver fluke infection,primary sclerosing cholangitis,and hepatolithiasis amongst others.These tumours are classified into intrahepatic,perihilar and distal based on their anatomical location.Morphologically,intrahepatic cholangiocarcinomas are further sub-classified into small and large duct variants.Perihilar and distal cholangiocarcinomas are usually mucin-producing tubular adenocarcinomas.Cholangiocarcinomas develop through a multistep carcinogenesis and are preceded by dysplastic and in situ lesions.While clinical characteristics and management of these tumours have been extensively elucidated in literature,their ultra-structure and tumour biology remain relatively unknown.This review focuses on the current knowledge of pathological characteristics,molecular alterations of cholangiocarcinoma,and its precursor lesions(including biliary intraepithelial neoplasia,intraductal papillary neoplasms of the bile duct,intraductal tubulopapillary neoplasms and mucinous cystic neoplasm).

关 键 词：CHOLANGIOCARCINOMA Classification PATHOLOGY Molecular features Precursors lesions Treatment 

分 类 号：R735.8[医药卫生—肿瘤]