Helicobacter pylori,gastric microbiota and gastric cancer relationship:Unrolling the tangle  

作　　者：Christos Liatsos Apostolis Papaefthymiou Nikolaos Kyriakos Michail Galanopoulos Michael Doulberis Marios Giakoumis Evangelia Petridou Christos Mavrogiannis Theodore Rokkas Jannis Kountouras 

机构地区：[1]Department of Gastroenterology,401 General Military Hospital of Athens,Athens 11525,Greece [2]Gastroenterology,University Hospital of Larissa,Larissa 41336,Greece [3]Division of Gastroenterology and Hepatology,Medical University Department,Kantonsspital Aarau,Aarau 1234,Switzerland [4]Department of Microbiology,“Agia Sofia”Paediatric Hospital,Goudi,Athens 11527,Greece [5]Gastrointestinal and Liver Unit,Faculty of Nursing,Kifissia General and Oncology Hospital,Kaliftaki,N.Kifisia 14564,Greece [6]Gastroenterological Clinic,Henry Dunant Hospital,Athens 11525,Greece [7]Department of Internal Medicine,Second Medical Clinic,Ippokration Hospital,Aristotle University of Thessaloniki,Thessaloniki 41336,Macedonia,Greece

出　　处：《World Journal of Gastrointestinal Oncology》2022年第5期959-972,共14页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：Helicobacter pylori infection(Hp-I)represents a typical microbial agent intervening in the complex mechanisms of gastric homeostasis by disturbing the balance between the host gastric microbiota and mucosa-related factors,leading to inflammatory changes,dysbiosis and eventually gastric cancer.The normal gastric microbiota shows diversity,with Proteobacteria[Helicobacter pylori(H.pylori)belongs to this family],Firmicutes,Actinobacteria,Bacteroides and Fusobacteria being the most abundant phyla.Most studies indicate that H.pylori has inhibitory effects on the colonization of other bacteria,harboring a lower diversity of them in the stomach.When comparing the healthy with the diseased stomach,there is a change in the composition of the gastric microbiome with increasing abundance of H.pylori(where present)in the gastritis stage,while as the gastric carcinogenesis cascade progresses to gastric cancer,the oral and intestinal-type pathogenic microbial strains predominate.Hp-I creates a premalignant environment of atrophy and intestinal metaplasia and the subsequent alteration in gastric microbiota seems to play a crucial role in gastric tumorigenesis itself.Successful H.pylori eradication is suggested to restore gastric microbiota,at least in primary stages.It is more than clear that Hp-I,gastric microbiota and gastric cancer constitute a challenging tangle and the strong interaction between them makes it difficult to unroll.Future studies are considered of crucial importance to test the complex interaction on the modulation of the gastric microbiota by H.pylori as well as on the relationships between the gastric microbiota and gastric carcinogenesis.

关 键 词：Helicobacter pylori infection Gastric microbiota Gastric cancer ONCOGENESIS DYSBIOSIS Helicobacter pylori eradication 

分 类 号：R735.2[医药卫生—肿瘤]