益生菌、益生元、合生元在肠易激综合征中的应用与最新进展  

Progress in application of probiotics,prebiotics,and synbiotics in irritable bowel syndrome

作　　者：朱柳艳 黄炳武 张雪良 朱宁[2] Liu-Yan Zhu;Bing-Wu Huang;Xue-Liang Zhang;Ning Zhu(Department of General Practice,The Third Affiliated Hospital of Shanghai University(Wenzhou People’s Hospital),Wenzhou 325000,Zhejiang Province,China;Department of Cardiology,The Third Affiliated Hospital of Shanghai University(Wenzhou People’s Hospital),Wenzhou 325000,Zhejiang Province,China;Department of Anesthesiology and Perioperative Medicine,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China)

机构地区：[1]上海大学附属第三医院(温州市人民医院)全科医学科,浙江省温州市325000 [2]上海大学附属第三医院(温州市人民医院)心血管内科,浙江省温州市325000 [3]温州医科大学附属第二医院麻醉医学科,浙江省温州市325000

出　　处：《世界华人消化杂志》2022年第8期375-380,共6页World Chinese Journal of Digestology

基　　金：浙江省医药卫生科技计划项目,No.2022RC205.

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)是一种常见的功能性肠病,主要表现为反复发作的腹痛伴排便频率和(或)粪便性状改变,腹痛常在排便后缓解,全球发病率呈逐年上升趋势.IBS引起的肠道症状(如便秘、腹泻、腹痛、腹胀等)及其伴随的一般神经系统功能的改变会显著降低患者的生活质量和工作效率,并造成一系列高额的医疗费用.因此,寻找安全、有效、经济的治疗方案成为近年的研究热点.研究表明IBS患者和健康受试者的肠道菌群有所不同,调节IBS患者的肠道菌群可治疗IBS.本综述的目的是总结益生菌、益生元、合生元通过调节肠道菌群治疗IBS的应用与最新进展.Irritable bowel syndrome(IBS)is a common functional bowel disorder characterized by recurrent abdominal pain accompanied by changes in defecation frequency and/or stool characteristics.The global incidence of IBS is increasing year by year.Intestinal symptoms caused by IBS(such as constipation,diarrhea,abdominal pain,and abdominal distension)and accompanying changes in general nervous system function can significantly reduce patients’quality of life and work efficiency,and lead to high medical costs.Therefore,finding safe,effective,and economical treatments has become a hot research topic in recent years.Studies have shown that the intestinal flora of patients with IBS is different from that of healthy subjects,and regulating the intestinal flora can treat IBS.The purpose of this review is to summarize the application and recent progress of probiotics,prebiotics,and synbiotics in the treatment of IBS by regulating the intestinal flora.

关 键 词：肠易激综合征 肠道菌群 治疗 益生菌 益生元 合生元 

分 类 号：R574.4[医药卫生—消化系统]