Skinny people serum factors promote the differentiation of multipotent stem cells into brown adipose tissue  

作　　者：Yuan-Long Gu Wei Shen Zhi-Peng Li Bo Zhou Zi-Jun Lin Lian-Ping He 

机构地区：[1]Department of Interventional Oncology,Municipal Hospital Affiliated to Taizhou University,Taizhou 318000,Zhejiang Province,China [2]School of Medicine Taizhou University,Taizhou University,Taizhou 318000,Zhejiang Province,China

出　　处：《World Journal of Stem Cells》2022年第4期314-317,共4页世界干细胞杂志（英文版）（电子版）

摘　　要：The original study by Alessio et al reported that skinny people (SP) serum canpromote the formation of brown adipocytes, but not the differentiation of whiteadipocytes. This finding may explain why SP do not often become obese, despiteconsuming more calories than the body needs. More importantly, theydemonstrated that circulating factors in SP serum can promote the expression ofUCP-1 protein, thereby reducing fat accumulation. In this study, only male serumsamples were evaluated to avoid the interference of sex hormones in experiments,but adult males also synthesize estrogen, which is produced by the cells of thetestes. At the same time, adult females secrete androgens, and females synthesizeandrogens that are mainly produced by the adrenal cortex. We believe that theapproach of excluding sex hormone interference by sex selection alone may beflawed, so we comment on the article and debate the statistical analysis of thearticle.

关 键 词：ANDROGEN CYTOKINE ESTROGEN GENDER Multipotent stem cell Obesity 

分 类 号：R589.2[医药卫生—内分泌]