Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer’s disease  

作　　者：Lin Wang Bi-Qiang Zhou Ying-Hong Li Qian-Qian Jiang Wei-Hong Cong Ke-Ji Chen Xiao-Min Wen Zheng-Zhi Wu 

机构地区：[1]The First Affiliated Hospital of Shenzhen University,Shenzhen Second People’s Hospital,Shenzhen Institute of Geriatrics,Shenzhen,Guangdong Province,China [2]The First Affiliated Hospital of Shenzhen University,Shenzhen Second People’s Hospital,Shenzhen,Guangdong Province,China [3]China Academy of Chinese Medical Sciences,Xiyuan Hospital,Beijing,China [4]School of Chinese Medicine,Southern Medical University,Guangzhou,Guangdong Province,China

出　　处：《Neural Regeneration Research》2023年第1期226-232,共7页中国神经再生研究（英文版）

基　　金：financially supported by Shenzhen Sanming Project of Medicine and Health, No. SZSM201612049 (to KJC);the Shenzhen Municipal Basic Research Project for Discipline Layout of China, No. JCYJ20170413161352000 (to YHL);Guangdong Basic Research Project, No. 2020A1515011427 (to ZZW)

摘　　要：Previous studies have shown that berberine has neuroprotective effects against Alzheimer’s disease,including antagonizing tau phosphorylation,and inhibiting acetylcholinesterase activity and neural cell apoptosis.However,its low bioavailability and adverse reactions with conventional administration limit its clinical application.In this study,we prepared berberine nanoliposomes using liposomes characterized by low toxicity,high entrapment efficiency,and biodegradability,and modified them with lactoferrin.Lactoferrin-modified berberine nanoliposomes had uniform particle size and high entrapment efficiency.We used the lactoferrin-modified berberine nanoliposomes to treat a mouse model of Alzheimer’s disease established by injection of amyloid-beta 1-42 into the lateral ventricle.Lactoferrin-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus,reduced tau over-phosphorylation in the cerebral cortex,and improved mouse behavior.These findings suggest that modification with lactoferrin can enhance the neuroprotective effects of berberine nanoliposomes in Alzheimer’s disease.

关 键 词：ACETYLCHOLINESTERASE Alzheimer’s disease apoptosis BERBERINE brain targeting LACTOFERRIN NANOLIPOSOMES neuroprotective effects Tau phosphorylation 

分 类 号：R749.16[医药卫生—神经病学与精神病学]