A near-infrared multifunctional fluorescent probe for hypoxia monitoring and tumor-targeted therapy  

作　　者：Yuxun Lu Jiajia Xu Zongyun Jia Siyu Kong Yimu Qiao Lin Li Qiong Wu Ying Zhou 

机构地区：[1]College of Chemical Science and Technology,Yunnan University,Kunming 650091,China [2]Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM),Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM),Nanjing Tech University(NanjingTech),Nanjing 211816,China

出　　处：《Chinese Chemical Letters》2022年第3期1589-1594,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 22067019);China-Sweden Joint Mobility Project(No. 51811530018);the Scientific Researchof Yunnan Provincial Department of Education (No. 2021Y031)。

摘　　要：Hypoxia is one of the key characteristics of solid tumors. The over-expression of azoreductase resulting from hypoxia can be used as a target to visualize hypoxic levels and a trigger of the drug release system in tumor treatment. In this work, we developed a near-infrared fluorescent probe YLOD, composed of a near-infrared fluorophore, an azo bond, and an analogue of the anti-tumor drug melphalan. In the presence of azoreductase, YLOD displayed a red emission at 620 nm and released the anti-tumor drug concomitantly, thus achieving the integrated effects of hypoxic imaging and tumor treatment. Furthermore, YLOD successfully inhibited the growth of solid tumors during the tumor suppression experiments in nude mice. Considering all the results, YLOD emerges as a new fluorescence tool that can quickly determine the location and the edges of a tumor, showing concrete potential in clinical cancer treatment.

关 键 词：AZOREDUCTASE HYPOXIA THERANOSTIC Tumor 

分 类 号：O657.3[理学—分析化学] R730.5[理学—化学]