Photoacoustic detection of follicular thyroid carcinoma using targeted Nano-Au-Tripods  

作　　者：Yang Gui Kai Cheng Ruojiao Wang Sirui Liu Chenyang Zhao Rui Zhang Ming Wang Zhen Cheng Meng Yang 

机构地区：[1]Department of Ultrasound,State Key Laboratory of Complex Severe and Rare Diseases,Pecking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [2]Molecular Imaging Program at Stanford(MIPS),Department of Radiology and Bio-X Program,School of Medicine,Stanford University,Stanford CA 94305-5484,USA

出　　处：《Chinese Journal of Chemical Engineering》2022年第4期1-7,共7页中国化学工程学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(81421004,81301268);Beijing Nova Program Interdisciplinary Cooperation Project (xxjc201812);International S&T Cooperation Program of China(2015DFA30440);Beijing Nova Program(Z131107000413063);CAMS Innovation Fund for Medical Sciences(CIFMS 2020-I2M-C&T-B-035)。

摘　　要：Follicular thyroid carcinoma(FTC)is the second most common form of thyroid malignancy,and it is associated with more aggressive growth and worse long-term survival outcomes relative to papillary thyroid carcinoma(PTC).Reliable approaches to preoperative FTC detection,however,remain to be established.Herein,a targeted Affibody-Au-Tripod nanoprobe was developed and successfully utilized to facilitate the targeted photoacoustic imaging(PAI)of epidermal growth factor receptor(EGFR)-positive cells and tumors.These Affibody-Au-Tripods were found to be highly sensitive and specific for cells expressing EGFR when used as a PA contrast agent in vitro,and studies conducted in an FTC-133 subcutaneous tumor model system in mice further revealed that these Affibody-Au-Tripods were able to specifically target these EGFR-expressing tumors while providing a strong photoacoustic signal in vivo.Importantly,these nanoprobes exhibited negligible cytotoxicity and robust chemical and physical stability,making Affibody-Au-Tripods promising candidates for targeted PAI-based FTC diagnosis.In addition,these nanoprobes have the potential to facilitate the individualized treatment of patients harboring EGFRpositive tumors.

关 键 词：AFFIBODY Follicular thyroid carcinoma Nano-Au-Tripods NANOPROBE Photoacoustic imaging 

分 类 号：R736.1[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]