云南高校图书馆联盟文献共享服务平台- AFFIBODY

AFFIBODY: 作品数：11被引量：7H指数：2; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王娜王士杰张敬勉韩静雅任秀春更多>>; 相关机构：温州医科大学河北医科大学第四医院厦门大学上海大学更多>>; 相关期刊：《病毒学报》《Nano-Micro Letters》《中华核医学与分子影像杂志》《化工科技》更多>>; 相关基金：国家自然科学基金河北省自然科学基金河北省普通高等学校强势特色学科基金陕西省自然科学基金更多>>

Evaluation of chicken chorioallantoic membrane model for tumor imaging and drug development:Promising findings: 《Animal Models and Experimental Medicine》2025年第2期287-294,共8页Lizhen Wang Junjie Yan XinyuWang Yuping Xu Donghui Pan Chongyang Chen Ying Shao Xiangjun Song Kezong Qi Min Yang Jian Tu; This study was supported by the National Natural Science Foundation of China(grant numbers:31972644,32272959);the University Synergy Innovation Program of Anhui Province(grant number:GXXT-2019-035);the Jiangsu Provincial Medical Innovation Team(grant number:CXTDA2017024);the leading technology foundation research project of Jiangsu Province(grant number:BK20192005).; Background:The chicken chorioallantoic membrane(CAM)model is a potential alter-native to the mouse model based on the 3R principles.However,its value for deter-mination of the in vivo behaviors of radiolabeled peptide...; 关键词：68Ga AFFIBODY chicken embryo CAM HER2 PET imaging

A self-assembled affibody-PROTAC conjugate nanomedicine for targeted cancer therapy: 《Nano Research》2024年第11期9954-9964,共11页Qingrong Li Xiaoyuan Yang Mengqiao Zhao Xuelin Xia Wenhui Gao Wei Huang Xiaoxia Xia Deyue Yan; supported by the National Natural Science Foundation of China(NOs.22201178,and 32071414);the National Key Research and Development Program of China(No.2020YFA0907702).; Proteolysis targeting chimeras (PROTACs) have recently emerged as promising therapeutic agents for cancer therapy. However, their clinical application is considerably hindered by the poor membrane permeability and ins...; 关键词：amphiphilic affibody-PROTAC conjugate BRD4 degradation NANOMEDICINE SELF-ASSEMBLY targeted cancer therapy

人乳头瘤病毒16/18型E7双特异亲和体融合颗粒酶B的免疫亲和毒素制备和鉴定: 《病毒学报》2023年第5期1326-1335,共10页余丽君李妍姮黄智羡杨佳妮谢自新张丽芳李文姝; 国家自然科学基金(项目号:81973216),题目:负载GrB双靶向HPV16/18亲和毒素抗宫颈癌生物学效应研究;浙江省基础公益研究计划项目(项目号:LY23C010003),题目:HPV16E7特异性免疫亲和毒素抗宫颈癌双功能作用及机制研究~~。; 制备人乳头瘤病毒(Human papilloma virus,HPV)16/18型双特异性亲和体(Affibody,Z_(HPV16-18E7))融合颗粒酶B(GrB)的免疫亲和毒素,并鉴定其诱导靶细胞凋亡效应。于实验室前期已构建的Z_(HPV16-18E7)的N-端、中间、及C-端,偶联GrB构建不...; 关键词：人乳头瘤病毒 HPV16/18型 AFFIBODY 颗粒酶B 双靶向细胞凋亡

Highly efficient tumor-targeted nanomedicine assembled from affibody-drug conjugate for colorectal cancer therapy被引量：2: 《Nano Research》2023年第4期5256-5264,共9页Xiaoyuan Yang Xuelin Xia Wei Huang Xiaoxia Xia Deyue Yan; supported by the National Key Research and Development Plan of China(No.2020YFA0907702);the National Facility for Translational Medicine(Shanghai)(No.TMST-2020-001).; Affibody is a new class of small non-immunoglobulin affinity proteins that possesses high affinity at the picomole level to several tumor overexpressed receptors.Owing to the simple framework,affibody is flexible for ...; 关键词：olecular self-assembly ZPDGFRβ:09591 affibody monomethyl auristatin E(MMAE) nanodrug targeted delivery

Affibody分子在生物技术和医学应用中的研究进展: 《化工科技》2022年第3期76-82,共7页郑蕾李欣禹成昭徐玥; 教育部“春晖计划”合作科研项目(14);陕西省卫生健康科研基金项目(2021E022);西安医学院校级科研项目(2021DXS57);陕西省自然科学基础研究计划面上项目(2021JM-489)。; Affibody分子,也被称为亲和体或者多肽适体探针,属于非抗体蛋白质的骨架结构。因其区别于一般抗体分子的结构特征,具有相对分子质量小、靶向性高、亲和力强,以及结构稳定、耐高温、可化学修饰等优势,因此Affibody的应用研究与发展迅速,...; 关键词：AFFIBODY 结构功能诊断肿瘤治疗

Photoacoustic detection of follicular thyroid carcinoma using targeted Nano-Au-Tripods被引量：2: 《Chinese Journal of Chemical Engineering》2022年第4期1-7,共7页Yang Gui Kai Cheng Ruojiao Wang Sirui Liu Chenyang Zhao Rui Zhang Ming Wang Zhen Cheng Meng Yang; supported by the National Natural Science Foundation of China(81421004,81301268);Beijing Nova Program Interdisciplinary Cooperation Project (xxjc201812);International S&T Cooperation Program of China(2015DFA30440);Beijing Nova Program(Z131107000413063);CAMS Innovation Fund for Medical Sciences(CIFMS 2020-I2M-C&T-B-035)。; Follicular thyroid carcinoma(FTC)is the second most common form of thyroid malignancy,and it is associated with more aggressive growth and worse long-term survival outcomes relative to papillary thyroid carcinoma(PTC)...; 关键词：AFFIBODY Follicular thyroid carcinoma Nano-Au-Tripods NANOPROBE Photoacoustic imaging

Self-Assembled Nanomicelles of Affibody-Drug Conjugate with Excellent Therapeutic Property to Cure Ovary and Breast Cancers被引量：2: 《Nano-Micro Letters》2022年第2期190-205,共16页Xuelin Xia Xiaoyuan Yang Wei Huang Xiaoxia Xia Deyue Yan; Research and Development Plan of China(No.2016YFA0201500,2020YFA0907702);National Facility for Translational Medi-cine(Shanghai)(No.TMST-2020-001)for financial support.; Affibody molecules are small nonimmunoglobulin affinity proteins,which can precisely target to some cancer cells with specific overexpressed molecular signatures.However,the relatively short in vivo half-life of them ...; 关键词：Molecular self-assembly Affibody-drug conjugate Nanoagent Targeted cancer therapy

Affibody靶向载自杀基因脂质纳米超声造影剂的制备及其特性的实验研究: 《中国临床医学影像杂志》2021年第9期669-673,共5页张月周厚妊罗语岑辛莹黄驰刘治军; 国家自然科学基金资助项目(编号81801712)。; 目的:制备一种包裹自杀基因和液态氟碳并具有Affibody靶向以及核定位效应的脂质纳米超声造影剂(UCAs),研究其基本特性及超声显影效果。方法:以前期课题组构建的含二硫键的聚氨基胺类聚合物CHL-CBA为核定位载体,构建基因载体复合物,采用...; 关键词：造影剂基因转基因自杀

HER2 affibody分子探针在放射免疫显像中的应用: 《放射学实践》2017年第6期650-654,共5页柏志成杨敏; 人类表皮生长因子受体2(HER2)是肿瘤重要的分子标志物之一,检测HER2表达对HER2阳性肿瘤的诊疗具有重要意义。放射免疫显像(RII)为在体HER2表达检测提供了一种更加准确、精细的方法,而灵敏、特异的分子探针则是进行放射免疫显像研究的先...; 关键词：HER2 分子探针放射免疫显像

Profiling EGFR in Triple Negative Breast Tumor Using Affibody PET Imaging: 《国际放射医学核医学杂志》2016年第5期329-337,共9页Yingding Xu Gang Ren Shibo Qi Zhen Cheng; 关键词：乳腺癌治疗方法临床分析医学研究

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

AFFIBODY

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

AFFIBODY

检索结果分析

下载全文

用户登录

高级检索检索式检索