左乙拉西坦治疗青少年肌阵挛癫痫的临床疗效及安全性评价  

Clinical Efficacy and Safety Evaluation of Levetiracetam in the Treatment of Juvenile Myoclonic Epilepsy

作　　者：梁艳[1] 刘肖[1] 邱敬锦 邓莉 LIANG Yan;LIU Xiao;QIU Jingjin;DENG Li(Department of Neurology,Second District,Xinyi People's Hospital of Guang dong Province,Xinyi,Guangdong Province,525300 China)

机构地区：[1]广东省信宜市人民医院神经内科二区,广东信宜525300

出　　处：《系统医学》2022年第10期76-78,87,共4页Systems Medicine

摘　　要：目的 分析左乙拉西坦(LEV)治疗青少年肌阵挛癫痫(JME)的临床疗效与安全性。方法 按照随机数表法将2019年3月—2021年2月该院神经内科收治的116例JME患者分为两组,各58例。A组采用LEV治疗,B组采用丙戊酸钠(VPA)治疗,比较两组临床疗效、脑电图改善情况及不良反应发生情况。结果 A组对肌阵挛发作(MS)、全面性强直阵挛发作(GTCS)的治疗总有效率为91.38%、94.83%,均略高于B组的86.21%、91.38%,但差异无统计学意义(P>0.05)。A组脑电图改善率略高于B组,但差异无统计学意义(P>0.05)。A组不良反应发生率为5.17%,低于B组的24.14%,差异有统计学意义(χ^(2)=8.340,P<0.05)。结论 LEV治疗JME的疗效与VPA相当,但安全性明显高于VPA,可作为临床治疗JME的首选一线抗癫痫药物。Objective To analyze the clinical efficacy and safety of levetiracetam(LEV) in the treatment of juvenile myoclonic epilepsy(JME).MethodsAccording to the random number table method,116 patients with JME admitted to the Department of Neurology in the hospital from March 2019 to February 2021 were divided into two groups,58cases in each group.Group A was treated with LEV,and group B was treated with sodium valproate(VPA).The clinical efficacy,EEG improvement and adverse reactions were compared between the two groups.ResultsThe total effective rates of myoclonic seizures(MS) and generalized tonic-clonic seizures(GTCS) in group A were 91.38% and94.83%,which were slightly higher than those in group B of 86.21% and 91.38%,but the difference was not statistically significant(P>0.05).The improvement rate of EEG in group A was slightly higher than that in group B,but the difference was not statistically significant(P>0.05).The incidence of adverse reactions in group A was 5.17%,which was lower than 24.14% in group B,and the difference was statistically significant(χ~2=8.340,P<0.05).Conclusion The efficacy of LEV in the treatment of JME is similar to that of VPA,but the safety is significantly higher than that of VPA.It can be used as the first-line antiepileptic drug for clinical treatment of JME.

关 键 词：青少年 肌阵挛癫痫 左乙拉西坦 临床疗效 安全性 

分 类 号：R74[医药卫生—神经病学与精神病学]