Evolution of tumor microenvironment in colorectal liver metastases under treatment stress  

作　　者：Na Huang Dongqiang Zeng Xiaoxiang Rong Chunlin Wang Zhenzhen Wu Jian Guo Yuqi Wang Jin Li Jing Li Jiao Wang Siting Zheng Genjie Huang Jianping Bin Yulin Liao Qian Li Xin Yi Wangjun Liao Min Shi 

机构地区：[1]Department of Oncology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,P.R.China [2]Department of Research and Development,GenePlus-Beijing,Beijing 102206,P.R.China [3]Department of Cardiology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,P.R.China

出　　处：《Cancer Communications》2022年第5期471-475,共5页癌症通讯（英文）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(81772580);Natural Science Foundation of Guangdong Province,China(2021A1515011705);the Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education(LC2016ZD014).

摘　　要：Dear editor,The tumor microenvironment(TME)heavily impacts disease biology and may influence responses to systemic treatments,and thereby,affects patients’prognosis.In our previous study,we found that immune features could predict prognosis and guide the therapy choices for stage I-III colon cancer[1,2].Increasing evidence shows that therapyinduced TME changes can promote tumor progression,metastasis,and the development of resistance[3,4].However,the TME dynamics in colorectal liver metastases(CRLM)under treatment are still incompletely clear.

关 键 词：COLORECTAL METASTASES TREATMENT 

分 类 号：R73[医药卫生—肿瘤]