Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes  

作　　者：Linpeng Li Keshi Chen Yi Wu Ge Xiang Xingguo Liu 

机构地区：[1]CAS Key Laboratory of Regenerative Biology,Joint School of Life Sciences,Guangzhou Medical University,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,Guangdong 510530,China [2]Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,China-New Zealand Joint Laboratory on Biomedicine and Health,CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine,Institute for Stem Cell and Regeneration,Guangzhou Institutes of Biomedicine and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Guangzhou,Guangdong 510530,China c [3]Centre for Regenerative Medicine and Health,Hong Kong Institute of Science&Innovation,Chinese Academy of Sciences,Hong Kong SAR,China

出　　处：《Journal of Genetics and Genomics》2022年第4期279-286,共8页遗传学报（英文版）

基　　金：financially supported by the National Key Research and Development Program of China (2017YFA0106300);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030505);the National Natural Science Foundation projects of China (2017YFA0102900, 2019YFA09004500, 2017YFC1001602, 2016YFA0100300, 2018YFA0107100);the National Natural Science Foundation projects of China (92157202, 32025010, 31801168, 31900614, 31970709, 81901275, 32070729, 32100619, 32170747);the Key Research Program of Frontier Sciences, CAS (QYZDB-SSW-SMC001);International Cooperation Program (154144KYSB20200006);Guangdong Province Science and Technology Program (2020B1212060052, 2018A030313825, 2018GZR110103002, 2020A1515011200, 2020A1515010919, 2020A1515011410, 2021A1515012513);Guangzhou Science and Technology Program (201807010067, 202002030277, 202102021250, 202102020827, 202102080066), Open Research Program of Key Laboratory of Regenerative Biology, CAS (KLRB201907, KLRB202014);CAS Youth Innovation Promotion Association (to Y. W. and K. C.)

摘　　要：Cell fate determination as a fundamental question in cell biology has been extensively studied at different regulatory levels for many years.However,the mechanisms of multilevel regulation of cell fate determination remain unclear.Recently,we have proposed an Epigenome-Metabolome-Epigenome(E-M-E)signaling cascade model to describe the cross-over cooperation during mouse somatic cell reprogramming.In this review,we summarize the broad roles of E-M-E signaling cascade in different cell biological processes,including cell differentiation and dedifferentiation,cell specialization,cell proliferation,and cell pathologic processes.Precise E-M-E signaling cascades are critical in these cell biological processes,and it is of worth to explore each step of E-M-E signaling cascade.E-M-E signaling cascade model sheds light on and may open a window to explore the mechanisms of multilevel regulation of cell biological processes.

关 键 词：Cell biological processes CHROMATIN EPIGENOME METABOLOME Signaling cascade 

分 类 号：Q23[生物学—细胞生物学]