Natural killer cells in obstetric antiphospholipid syndrome  

作　　者：Rongxiu Huo Qianyu Guo Junping Hu Na Li Hechao Liu Zhaoliang Zhang Liangyu Mi Xinyue Peng Liyun Zhang Ke Xu 

机构地区：[1]Department of Rheumatology and Immunology,Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxl Hospital,Taiyuan,Shanxi 030032,China [2]Department of Immunology,Shanxi Medical University,Taiyuan,Shanxi 030000,China

出　　处：《Chinese Medical Journal》2022年第7期790-792,共3页中华医学杂志（英文版）

基　　金：the National Natural Science Foundation of China(No.81871292);the Key Research and Development(R&D)Projects of Shanxi Province(No.201803D31136)。

摘　　要：Antiphospholipid syndrome(APS)is a systemic autoimmune disease characterized by thrombotic or obstetric events caused by persistent antiphospholipid antibodies(aPLs),namely lupus anticoagulant,anticardiolipin antibodies,or anti-β2 glycoprotein I(anti-β2GPI)antibodies.^([1])The main target antigen in APS isβ2GPI,through which aPL binds to the cell membrane and subsequently activates membrane receptors and down-stream signal transducers.This may activate natural killer(NK)cells,leading to obstetric complications.

关 键 词：KILLER ANTIBODIES GLYCOPROTEIN 

分 类 号：R392[医药卫生—免疫学]