Role of main RNA modifications in cancer:N^(6)-methyladenosine,5-methylcytosine,and pseudouridine  

作　　者：Chen Xue Qingfei Chu Qiuxian Zheng Shiman Jiang Zhengyi Bao Yuanshuai Su Juan Lu Lanjuan Li 

机构地区：[1]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第5期1555-1585,共31页信号转导与靶向治疗（英文）

基　　金：This work was funded by the National Key Research and Development Program of China(2021YFC2301800);the National Nature Science Foundation of China(U20A20343);Zhejiang University Academic Award for Outstanding Doctoral Candidates(2020055).

摘　　要：Cancer is one of the major diseases threatening human life and health worldwide.Epigenetic modification refers to heritable changes in the genetic material without any changes in the nucleic acid sequence and results in heritable phenotypic changes.Epigenetic modifications regulate many biological processes,such as growth,aging,and various diseases,including cancer.With the advancement of next-generation sequencing technology,the role of RNA modifications in cancer progression has become increasingly prominent and is a hot spot in scientific research.This review studied several common RNA modifications.

关 键 词：DISEASES CANCER CANCER 

分 类 号：R730.2[医药卫生—肿瘤]