Correlations between phytohemagglutinin response and leukocyte profile,and bactericidal capacity in a wild rodent  

作　　者：Zhiqiang ZHANG Zhijun ZHAO 

机构地区：[1]College of Animal Science and Technology,Anhui Agricultural University,Hefei,China [2]College of Life and Environmental Science,Wenzhou University,Wenzhou,China

出　　处：《Integrative Zoology》2015年第3期302-310,共9页整合动物学（英文版）

基　　金：This study was supported by a Key Project of Natural Science of the Anhui Province Department of Education,China(KJ2011A114);supported by the State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,The Chinese Academy of Sciences(ChineseIPM1001)to ZZQ.

摘　　要：phytohemagglutinin(PHA)-induced swelling is widely used to investigate cell-mediated and innate immunity across different vertebrate taxa.However,its physiological mechanism is still an open question due to the complexity of the involved immune components.In the present study,we measured the synchronous variations of PHA response,the proportion of different subtypes of leukocytes,as well as serum bactericidal capacity in circulation blood at 6,12 and 24 h after PHA versus PBS injection in striped hamster,Cricetulus barabensis.First,the results showed that PHA responses reached a peak at 6 h postinjection,then sharply declined at 12 h and 24 h postinjection.Serum bactericidal capacity was higher at 6 h and 12 h than at 24 h.The proportion of different subtypes of leukocytes,as well as the ratio of neutrophils to lymphocytes did not display significant changes across different time points.Second,PHA response was positively correlated with the proportion of neutrophils and serum bactericidal capacity.The proportion of monocytes was negatively correlated with that of eosinophils and neutrophils.The proportion of basophils was negatively correlated with that of lymphocytes.Our results indicate that earlier enhanced PHA response is important for the striped hamster to cope with changing environmental conditions due to its small body mass,and the increased components of innate immunity in circulation blood may contribute to the enhancement of PHA swelling response.

关 键 词：Cricetulus barabensis NEUTROPHILS PHYTOHEMAGGLUTININ serum bactericidal capacity striped hamster 

分 类 号：R73[医药卫生—肿瘤]