Mesenchymal stem cell-derived exosomes as new remedy for the treatment of inflammatory eye diseases  

作　　者：CARL RANDALL HARRELL ANA VOLAREVIC DRAGICA PAVLOVIC VALENTIN DJONOV VLADISLAV VOLAREVIC 

机构地区：[1]Regenerative Processing Plant,Palm Harbor,Florida,USA [2]Department of Cognitive Psychology,Faculty of Medical Sciences,University of Kragujevac,Kragujevac,Serbia [3]Institute of Anatomy,University of Bern,Bern,Switzerland [4]Department of Genetics,Faculty of Medical Sciences,University of Kragujevac,Kragujevac,Serbia [5]Department of Microbiology and Immunology,Faculty of Medical Sciences,University of Kragujevac,Kragujevac,Serbia

出　　处：《BIOCELL》2022年第10期2195-2200,共6页生物细胞（英文）

基　　金：This work was supported by European Crohn’s and Colitis Organization(ECCO)(Grant“The role of galectin 3 in acute colitis”),Serbian Ministry of Science(Grant Nos.ON175069 and ON175103);Faculty of Medical Sciences University of Kragujevac(Grant No.MP01/18).

摘　　要：Detrimental immune response has a crucially important role in the development and progression of inflammatory eye diseases.Inflammatory mediators and proteolytic enzymes released by activated immune cells induce serious injury of corneal epithelial cells and retinal ganglion cell which may result in the vision loss.Mesenchymal stem cells(MSCs)are regulatory cells which produce various immunosuppressive factors that modulate phenotype and function of inflammatory immune cells.However,several safety issues,including undesired differentiation and emboli formation,limit clinical use of MSCs.MSC-derived exosomes(MSC-Exos)are nano-sized extracellular vesicles which contain all MSC-derived immunoregulatory factors.Intraocular administration of MSCExos efficiently attenuated eye inflammation and significantly improved visual acuity in experimental animals without causing any severe side effects.As cell-free product,MSC-Exos addressed all safety issues related to the transplantation of MSCs.Therefore,MSC-Exos could be considered as potentially new remedy for the treatment of inflammatory eye diseases which efficacy should be explored in up-coming clinical trials.

关 键 词：Mesenchymal stem cells EXOSOMES INFLAMMATION Eye THERAPY 

分 类 号：R73[医药卫生—肿瘤]