Antimalarial drug artesunate affords protection against carrageenan induced acute inflammation in rat  

作　　者：Vijay L.KUMAR B.GURUPRASAD Priyanka CHAUDHARY 

机构地区：[1]Department of Pharmacology,All India Institute of Medical Sciences,Ansari Nagar,New Delhi-110029,India [2]Department of Plant Molecular Biology,Delhi University South Campus,Benito Juarez Road,Dhaula Kuan,New Delhi-110021,India.

出　　处：《BIOCELL》2014年第1期1-5,共5页生物细胞（英文）

基　　金：research grant(A-059)from All India Institute of Medical Sciences,New Delhi.Artesunate and diclofenac were kind gifts from Arbro Pharmaceuticals Ltd.,New Delhi.

摘　　要：Artesunate, an antimalarial drug, has been shown to inhibit the release of inflammatory mediators in various disease conditions. The present study was carried out to evaluate the anti-edematogenic effect of arte- sunate in the rat paw edema model. Inflammation was induced in the hind paw of rat by sub-plantar injection of 0.1 mL of 0.5% carrageenan and the paw volume was measured up to a fixed mark just before the injection and then after 3 h. The difference in two volumes gave a measure of edema formation. At 3h the level of TNF-α, PGE_(2) and myeloperoxidase were estimated in the inflamed paw tissue. Treatment of rats with single dose of artesunate at 50 and 150 mg/kg produced a dose-dependent inhibition in paw inflammation where a significant reduction in edema volume and mediator release was observed. Our study shows that by inhibiting the release of inflam- matory mediators artesunate affords protection against acute inflammation induced in the rat paw and suggests that it has a potential to be used in the treatment of inflammatory disease conditions.

关 键 词：ARTESUNATE EDEMA MYELOPEROXIDASE TNF-α PGE_(2) 

分 类 号：R57[医药卫生—消化系统]