Entrainment of Astrocytic and Neuronal Ca^(2+) Population Dynamics During Information Processing of Working Memory in Mice  

作　　者：Zhu Lin Feng You Ting Li Yijia Feng Xinyue Zhao Jingjing Yang Zhimo Yao Ying Gao Jiang-Fan Chen 

机构地区：[1]The Molecular Neuropharmacology Laboratory and the EyeBrain Research Center,State Key Laboratory of Ophthalmology,Optometry and Visual Science,School of Optometry and Ophthalmology and Eye Hospital,Wenzhou Medical University,Wenzhou 325035,China

出　　处：《Neuroscience Bulletin》2022年第5期474-488,共15页神经科学通报（英文版）

基　　金：This work was supported by Start-up Funds from Wenzhou Medical University(89211010 and 89212012);the National Natural Science Foundation of China(81630040,31771178,and 81600991);the Natural Science Foundation of Zhejiang Province of China(LY21H090014 and LQ18C090002).

摘　　要：Astrocytes are increasingly recognized to play an active role in learning and memory,but whether neural inputs can trigger event-specific astrocytic Ca^(2+)dynamics in real time to participate in working memory remains unclear due to the difficulties in directly monitoring astrocytic Ca^(2+)dynamics in animals performing tasks.Here,using fiber photometry,we showed that population astrocytic Ca^(2+)dynamics in the hippocampus were gated by sensory inputs(centered at the turning point of the T-maze)and modified by the reward delivery during the encoding and retrieval phases.Notably,there was a strong inter-locked and antagonistic relationship between the astrocytic and neuronal Ca^(2+)dynamics with a 3-s phase difference.Furthermore,there was a robust synchronization of astrocytic Ca^(2+)at the population level among the hippocampus,medial prefrontal cortex,and striatum.The inter-locked,bidirectional communication between astrocytes and neurons at the population level may contribute to the modulation of information processing in working memory.

关 键 词：Working memory Ca^(2+)dynamics ASTROCYTE Neuron Fiber photometry HIPPOCAMPUS 

分 类 号：R74[医药卫生—神经病学与精神病学]