Synthesis of 2-Deoxy-C-Glycosides via Iridium-Catalyzed sp^(2)and sp^(3)C-H Glycosylation with Unfunctionalized Glycals  

作　　者：Wanjun Zhu Qikai Sun Hai Chang Hui-Xing Zhang Quanquan Wang Gong Chen Gang He 

机构地区：[1]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin,300071 China

出　　处：《Chinese Journal of Chemistry》2022年第5期571-576,共6页中国化学（英文版）

基　　金：We gratefully acknowledge the National Natural Science Foundation of China(NSFC 21725204,NSFC-22071119);the“111”project(B06005)of MOE China,and NCC2020FH02 for financial support of this work.

摘　　要：A new protocol for the synthesis of 2-deoxy-C-aryl-glycosides and 2-deoxy-C-alkyl-glycosides via iridium-catalyzed directed C—H glycosylation with glycals is reported.The method is amenable for both the C_(2)C—H glycosylation of indoles and the methyl C—H glycosylation of secondary methyl amines under the control of an N-linked benzoxazole directing group.The benzoxazole group can be cleanly removed by the treatment of KOH or LiAlH_(4).

关 键 词：2-Deoxy-C-glycoside IRIDIUM C-Hactivation GLYCOSYLATION GLYCALS 

分 类 号：O62[理学—有机化学]