Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers  

作　　者：Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman 

机构地区：[1]Sharjah Institute for Medical Research,University of Sharjah,Sharjah 27272,United Arab Emirates [2]College of Medicine,University of Sharjah,Sharjah 27272,United Arab Emirates [3]Department of Clinical Sciences,University of Sharjah,Sharjah 27272,United Arab Emirates [4]Department of Basic Medical Sciences,University of Sharjah,Sharjah 27272,United Arab Emirates [5]Department of Medical Laboratory Sciences,University of Sharjah,Sharjah 27272,United Arab Emirates [6]Department of Biomedical Sciences,University of Sassari,Sassari 07100,Italy [7]University Cancer Center Schleswig-Holstein and Luebeck Institute for Experimental Dermatology,University of Luebeck,Luebeck 23560,Germany [8]Institute of Pathology,University Hospital Schleswig-Holstein,Luebeck 23560,Germany [9]Division of Surgery and Interventional Science,University College London,London WC1E 6BT,United Kingdom

出　　处：《World Journal of Gastrointestinal Oncology》2022年第9期1637-1653,共17页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer.

关 键 词：Bladder cancer CALD1 CALDESMON CHEMORESISTANCE Colorectal cancer Gastric cancer GLIOMA Epithelial to mesenchymal transition Invasion Metastasis 

分 类 号：R735.34[医药卫生—肿瘤]