Photobiomodulation therapy for osteoarthritis: Mechanisms of action  

作　　者：Fábio Pericinoto Giolo Gabriel Silva Santos Victor Fontes Pacheco Stephany Cares Huber Kaue Franco Malange Bruno Lima Rodrigues Fernanda Bassora Tomas Mosaner Gabriel Azzini Lucas Leite Ribeiro Carlos Amilcar Parada JoséFábio Santos Duarte Lana 

机构地区：[1]Department of Physical Therapy,Brazilian Institute of Regenerative Medicine,Indaiatuba 13334-170,Brazil [2]Biomedical Science,Brazilian Institute of Regenerative Medicine,Indaiatuba 13334-170,Brazil [3]Department of Orthopedics,Brazilian Institute of Regenerative Medicine,Indaiatuba 13334-170,Brazil [4]Neurobiology of Pain and Regenerative Medicine,The University of Campinas,Campinas 13083-862,Brazil [5]Department of Hematology,The University of Campinas,Campinas 13083-878,Brazil

出　　处：《World Journal of Translational Medicine》2022年第3期29-42,共14页世界转化医学杂志

摘　　要：Photobiomodulation(PBM)is a non-invasive therapeutic modality with demonstrated effects in many fields related to regenerative medicine.In the field of orthopedics,in particular,PBM at various wavelengths has demonstrated the capacity to trigger multiple biological effects associated with protective mechanisms in musculoskeletal tissues.The articles cited in this review show that devices operating close to or within the near infrared range at low intensities can provoke responses which favor the shift in the predominant catabolic microenvironment typically seen in degenerative joint diseases,especially osteoarthritis(OA).These responses include proliferation,differentiation and expression of proteins associated with stable cell cycles.Additionally,PBM can also modulate oxidative stress,inflammation and pain by exerting regulatory effects on immune cells and blocking the transmission of pain through sensory neuron fibers,without adverse events.Collectively,these effects are essential in order to control the progression of OA,which is in part attributed to exacerbated inflammation and degradative enzymatic reactions which gradually contribute to the destruction of joint tissues.PBM may offer medical experts ease of application,financial viability,efficacy and lack of serious adverse events.Therefore,it may prove to be a suitable ally in the management of mild to moderate degrees of OA.This review explores and discusses the principal biological mechanisms of PBM and how the produced effects may contribute to the amelioration of osteoarthritic progression.Literature was reviewed using PubMed and Google Scholar in order to find studies describing the mechanisms of PBM.The investigation included a combination of nomenclature such as:“photobiomodulation”,“phototherapy”,“laser therapy”,“PBM”,“osteoarthritis”,low level light therapy”,“inflammation”and“cartilage”.We considered only articles written in English,with access to the full text.

关 键 词：PHOTOBIOMODULATION Low-level laser therapy OSTEOARTHRITIS INFLAMMATION Regenerative medicine 

分 类 号：R73[医药卫生—肿瘤]